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Prevalence Of Microalbuminuria Among Children Suffering From Sickle Cell Nephropathy and Sickle Cell/Beta-Thalassemia

The recruitment status of this study is unknown because the information has not been verified recently.
Verified March 2010 by Hillel Yaffe Medical Center.
Recruitment status was  Not yet recruiting
Sponsor:
Information provided by:
Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier:
NCT01092169
First received: March 23, 2010
Last updated: NA
Last verified: March 2010
History: No changes posted
  Purpose

Sickle cell nephropathy is a known complication of sickle cell anemia (SCA) manifested by increase in glomerular filtration rate (glomerular hyperfiltration) and results in proteinuria and chronic renal failure.

Our goal is to examine the prevalence of proteinuria and microalbuminuria as an early predictive factor of glomerular injury, among young people who suffer from SCA as well as those who suffer from combined sickle cell/beta-thalassemia.


Condition Intervention
Sickle Cell Anemia
Beta-Thalassemia
Microalbuminuria
 Other: No intervention

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Cross-Sectional

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Hillel Yaffe Medical Center:

Groups/Cohorts Assigned Interventions
Sickle cell beta Other: No intervention

  Eligibility

Ages Eligible for Study:   up to 25 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

Young people suffering from SCA as well as those who suffer from combined sickle cell/beta-thalassemia, between 0-25 years old.

Criteria

Inclusion Criteria:

  • Patients diagnosed with sickle cell anemia
  • Patients diagnosed with combined sickle cell anemia/beta-thalassemia

Exclusion Criteria:

  • Diabetes mellitus
  • Hypertension
  • Reduced renal mass (single kidney)
  • Overweight
  • History of UTIs
  Contacts and Locations
No Contacts or Locations Provided
  More Information

No publications provided

Responsible Party: Amit Hochberg, Pediatrics Department, Hillel Yaffe Medical Center
ClinicalTrials.gov Identifier: NCT01092169     History of Changes
Other Study ID Numbers: 64/2009
Study First Received: March 23, 2010
Last Updated: March 23, 2010
Health Authority: Israel: Ministry of Health

Additional relevant MeSH terms:
Beta-Thalassemia
Anemia
Anemia, Sickle Cell
Thalassemia
Albuminuria
Hematologic Diseases
Anemia, Hemolytic, Congenital
Anemia, Hemolytic
 Hemoglobinopathies
Genetic Diseases, Inborn
Proteinuria
Urination Disorders
Urologic Diseases
Urological Manifestations
Signs and Symptoms

ClinicalTrials.gov processed this record on May 16, 2013