Regulation of Intraarticular and Synovium-related Biomarkers of Osteoarthritis. Effect of Acute Mechanical Joint Loading

This study has been completed.
Sponsor:
Collaborators:
The Danish Rheumatism Association
Danish Ministry of Health, Internal Affairs
Danish National Research Council
The Danish Medical Research Council
Information provided by:
Bispebjerg Hospital
ClinicalTrials.gov Identifier:
NCT01090375
First received: March 18, 2010
Last updated: NA
Last verified: March 2010
History: No changes posted
  Purpose

In the present study the microdialysis method is used to investigate biochemical changes within and around the joint simultaneously in both the resting state and in a joint that had been subjected to exercise. The aim of the present study was, by applying the microdialysis technique, to monitor markers of cartilage breakdown and inflammation in 2 different positions of the knee (inside and in the inner part of the knee capsule) in a group of human females with knee osteoarthritis over a period of 3 hours.


Condition Intervention Phase
Osteoarthritis
Exercise
Other: Exercise
Other: Non Exercise
Phase 0

Study Type: Interventional
Study Design: Intervention Model: Parallel Assignment
Primary Purpose: Basic Science

Resource links provided by NLM:


Further study details as provided by Bispebjerg Hospital:

Study Start Date: August 2008
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: Exercise Other: Exercise
Placebo Comparator: Non Exercise Other: Non Exercise

  Eligibility

Ages Eligible for Study:   55 Years to 75 Years
Genders Eligible for Study:   Female
Criteria

Inclusion Criteria:

  • verified osteoarthritis (x-ray)of the knee, female,

Exclusion Criteria:

  • dementia, inflammatory diseases, regular pain medication
  Contacts and Locations
No Contacts or Locations Provided
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT01090375     History of Changes
Other Study ID Numbers: H-KF-306126
Study First Received: March 18, 2010
Last Updated: March 18, 2010
Health Authority: Denmark: The Danish National Committee on Biomedical Research Ethics

Keywords provided by Bispebjerg Hospital:
osteoarthritis
biochemical markers
cartilage
inflammation
microdialysis

Additional relevant MeSH terms:
Osteoarthritis
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases

ClinicalTrials.gov processed this record on April 17, 2014