A Linkage and Association Study in Pulmonary Fibrosis (GWAS)
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Purpose
The purpose of this study is to investigate inherited genetic factors that play a role in the development of familial pulmonary fibrosis and to identify a group of genes that predispose individuals to develop pulmonary fibrosis. Finding the genes that cause pulmonary fibrosis is the first step at developing better methods for early diagnosis and improved treatment for pulmonary fibrosis. The overall hypothesis is that inherited genetic factors predispose individuals to develop pulmonary fibrosis.
| Condition |
|---|
|
Idiopathic Pulmonary Fibrosis Familial Pulmonary Fibrosis Idiopathic Interstitial Pneumonia Familial Interstitial Pneumonia |
| Study Type: | Observational |
| Study Design: | Observational Model: Family-Based Time Perspective: Cross-Sectional |
| Official Title: | GWAS in Fibrosing Interstitial Lung Disease |
whole blood, serum, plasma, lung tissue, DNA, RNA
| Estimated Enrollment: | 8000 |
| Study Start Date: | July 2008 |
| Estimated Study Completion Date: | July 2018 |
| Estimated Primary Completion Date: | July 2018 (Final data collection date for primary outcome measure) |
Familial Pulmonary Fibrosis (FPF) is a sub-category of the idiopathic interstitial pneumonias (IIPs). IIPs are progressive lung conditions, with limited treatment options and unknown etiology. Though the IIPs have been associated with both genetic risk factors and environmental exposures, the molecular mechanism underlying disease progression remain poorly understood. This investigation seeks to identify a group of genetic loci that play a role in the development of familial interstitial pneumonia (FIP) or FPF, where 2 or more cases of IIP are seen within a family.
Eligibility| Ages Eligible for Study: | 7 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Families with two or more individuals diagnosed with Idiopathic Pulmonary Fibrosis (IPF) or Idiopathic Interstitial Pneumonia (IIP)
Inclusion Criteria:
- Two or more family members with a clinical diagnosis of Idiopathic Pulmonary Fibrosis (IPF) or Idiopathic Interstitial Pneumonia (IIP)
- Additional family members may be eligible to participate if two family members are suspected of or diagnosed as having Idiopathic Pulmonary Fibrosis (IPF) or Idiopathic Interstitial Pneumonia (IIP)
Exclusion Criteria:
- Individuals whose pulmonary fibrosis is due to a known cause rather than idiopathic
- Individuals whose pulmonary fibrosis is due to a broader genetic syndrome
Contacts and Locations| Contact: Janet Talbert, MS, CGC | 800-423-8891 ext 1022 | talbertj@njhealth.org |
| United States, Colorado | |
| National Jewish Health and University of Colorado Denver | Recruiting |
| Denver, Colorado, United States, 80206 | |
| Contact: Janet Talbert, MS, CGC 800-423-8891 ext 1022 talbertj@njhealth.org | |
| Principal Investigator: David A. Schwartz, MD | |
| Sub-Investigator: Kevin K. Brown, MD | |
| Sub-Investigator: Gregory P. Cosgrove, MD | |
| Sub-Investigator: Marvin I. Schwarz, MD | |
| Sub-Investigator: Tasha Fingerlin, PhD | |
| Sub-Investigator: Steve Groshong, MD, PhD | |
| Sub-Investigator: David Lynch, MD | |
| United States, Tennessee | |
| Vanderbilt University | Recruiting |
| Nashville, Tennessee, United States, 37232 | |
| Contact: Cheryl Markin, MT 888-898-1550 cheryl.markin@vanderbilt.edu | |
| Principal Investigator: James E. Loyd, MD | |
| Iceland | |
| Landspitali University Hospital | Recruiting |
| Reykjavik, Iceland | |
| Principal Investigator: Gunnar Gudmundsson, MD | |
| Principal Investigator: | David A. Schwartz, MD | University of Colorado Denver; National Jewish Health |
More Information
Additional Information:
No publications provided
| Responsible Party: | National Jewish Health |
| ClinicalTrials.gov Identifier: | NCT01088217 History of Changes |
| Other Study ID Numbers: | 1RO1HL097163 |
| Study First Received: | March 15, 2010 |
| Last Updated: | March 14, 2012 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by National Jewish Health:
|
Idiopathic Pulmonary Fibrosis Familial Pulmonary Fibrosis Idiopathic Interstitial Pneumonia Familial Interstitial Pneumonia Pulmonary Fibrosis |
Additional relevant MeSH terms:
|
Fibrosis Pneumonia Pulmonary Fibrosis Lung Diseases, Interstitial Idiopathic Interstitial Pneumonias |
Idiopathic Pulmonary Fibrosis Pathologic Processes Lung Diseases Respiratory Tract Diseases Respiratory Tract Infections |
ClinicalTrials.gov processed this record on May 19, 2013