Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial

This study has been completed.
Sponsor:
Information provided by:
Universidade Católica de Pelotas
ClinicalTrials.gov Identifier:
NCT01076881
First received: February 17, 2010
Last updated: February 25, 2010
Last verified: February 2010
  Purpose

This is a randomized trial with participants recruited from one dialysis unit of a Brazilian university hospital. Hemodialysis patients were assigned to receive the resistance exercise combined with an aerobic training or the resistance training alone for a period of 10 weeks. The functional performance of patients was assessed before and after the intervention through the six-minute walk test (6MWT). The difference over time of the 6MWT was compared between the groups through multivariate linear regression.

Thirteen patients were allocated for each group of intervention. The difference in distance walked before and after intervention in the combined training group was of +39.7 (61.4) meters, and this difference in the resistance training group was of -19.2 (53.9) meters, p=0.01. In multivariate analysis with adjustment for age, skin color, gender, hematocrit, time since starting dialysis, Kt/V and baseline values of 6MWT, the type of training remained significantly associated with the amount of increase in walked distance.

Although the best protocol of exercise for patients on dialysis is not yet clear, in the investigators sample of hemodialysis patients the combination of aerobic and resistance training was more effective to improve functional performance.


Condition Intervention
End Stage Renal Disease
Behavioral: exercise training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Supportive Care
Official Title: Combined Resistance and Aerobic Exercise is Better Than Resistance Training Alone to Improve Functional Performance of Hemodialysis Patients - Results of a Randomized Trial

Resource links provided by NLM:


Further study details as provided by Universidade Católica de Pelotas:

Primary Outcome Measures:
  • physical performance [ Time Frame: 10 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • dialysis adequacy (KtV) [ Time Frame: 4/8/10 weeks ] [ Designated as safety issue: No ]

Enrollment: 26
Study Start Date: December 2008
Study Completion Date: March 2009
Primary Completion Date: March 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: combined aerobic and resistance training Behavioral: exercise training
Active Comparator: resistance training alone Behavioral: exercise training

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • to be on hemodialysis therapy for longer than 3 months
  • to be already included in the resistance training protocol during dialysis
  • to receive erythropoietin for the treatment of anemia
  • hemoglobin level greater than 9.0 g/dL
  • to be able to maintain sitting and standing balance and ambulatory without assistance.

Exclusion Criteria:

  • symptomatic ischemic heart disease
  • recent myocardial infarction of less than 6 months
  • uncontrolled hypertension
  • pericardial or pleural friction rub
  • aortic stenosis
  • active musculoskeletal lower-extremity problem, or history of vertebral fracture caused by osteoporosis
  • patients were also excluded if they participated in formal organized exercise programs outside the dialysis unit.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01076881

Locations
Brazil
Hospital Universitário São Francisco de Paula
Pelotas, RS, Brazil
Sponsors and Collaborators
Universidade Católica de Pelotas
  More Information

No publications provided

ClinicalTrials.gov Identifier: NCT01076881     History of Changes
Other Study ID Numbers: UCPelotas01
Study First Received: February 17, 2010
Last Updated: February 25, 2010
Health Authority: Brazil: Ethics Committee

Additional relevant MeSH terms:
Kidney Diseases
Kidney Failure, Chronic
Urologic Diseases
Renal Insufficiency, Chronic
Renal Insufficiency

ClinicalTrials.gov processed this record on July 28, 2014