Biomarkers in Bone Marrow Samples From Pediatric Patients With High-Risk Acute Myeloid Leukemia
Recruitment status was Active, not recruiting
RATIONALE: Studying samples of bone marrow from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer.
PURPOSE: This research study is studying biomarkers in bone marrow samples from pediatric patients with high risk acute myeloid leukemia.
Genetic: DNA methylation analysis
Genetic: gene expression analysis
Genetic: gene mapping
Genetic: loss of heterozygosity analysis
Genetic: polymorphism analysis
Other: laboratory biomarker analysis
|Official Title:||Target Identification for High Risk Childhood AML Based on Genome-Wide Analysis|
- Detailed molecular map of pediatric high-risk acute myeloid leukemia [ Designated as safety issue: No ]
|Study Start Date:||March 2010|
|Estimated Primary Completion Date:||March 2010 (Final data collection date for primary outcome measure)|
- To determine whether the detailed mapping of transcription, gene copy number, loss of heterozygosity status, and genomic methylation patterns will reveal novel changes that can refine risk-group stratification and be therapeutically targeted in pediatric patients with high-risk acute myeloid leukemia.
OUTLINE: This is a multicenter study.
Banked bone marrow samples from diagnosis and remission are used to develop a detailed molecular map of pediatric high-risk acute myeloid leukemia. Analysis includes genome SNP genotyping, expression, and methylation profiling.
|Principal Investigator:||Soheil Meshinchi, MD||Fred Hutchinson Cancer Research Center|