Corneal Endothelium Cell Loss After Cataract Extraction in Patients Taking Tamsulosin
The purpose of this study is to determine whether corneal endothelium cell loss during cataract surgery is higher in patients taking Tamsulosin.
|Study Design:||Observational Model: Case Control
Time Perspective: Prospective
|Official Title:||Corneal Endothelium Cell Loss After Cataract Extraction in Patients Taking Systemic Sympathetic Alfa-1-a-antagonist Medication (Tamsulosin)|
- corneal endothelium cell loss [ Time Frame: 3 months ] [ Designated as safety issue: No ]Corneal endothelium cells was evaluated by specular microskopy before and 3 month post-operatively.
|Study Start Date:||June 2009|
|Study Completion Date:||September 2010|
|Primary Completion Date:||September 2010 (Final data collection date for primary outcome measure)|
Patients taking tamsulosin
Patients not taking tamsulosin.
Cataract surgery in patients taking Tamsulosin is regarded as more challenging for the surgeon because Intraoperative Floppy Iris Syndrome (IFIS) might occur. However, the question is whether this has any practical implication for the outcomes of surgery. In this study we investigate whether cornea is damage during surgery on Tamsulosin patient. In an observational study 30 cataract patients taking Tamsulosin is compared to 30 patients not taking Tamsulosin, but otherwise similar. Number of patients is based on power calculation.
Cornea is examined by specular microscopy.
Please refer to this study by its ClinicalTrials.gov identifier: NCT01076309
|Frederiksberg University Hospital|
|Frederiksberg, Denmark, 2000|