Exercise Training Effects in Patients With Heart Failure
Chronic heart failure (CHF) is a common syndrome characterized by several central hemodynamic and peripheral vascular and muscle abnormalities including autonomic imbalance, neuro-hormonal over-activation and decreased oxidative status.
In patients suffering from CHF, exercise confers several beneficial effects on the cardiovascular and peripheral systems, mainly by continuous aerobic training. However, interval aerobic training has also been validated as an alternate form of training that increases the exercise capacity of patients who are in CHF.
Recent studies have suggested that resistance training alone or as a complementary program besides the traditionally aerobic continuous training might exert favorable effects. However, little it is known about the combined effects of interval and strength training in CHF patients.
Aim of this prospective randomized controlled study was to investigate the effects of combined interval and strength training comparing to interval training alone in CHF patients.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Aerobic Interval Training Versus Combined Aerobic Interval Training and Strength Training Effects in Patients With Heart Failure|
- Aerobic exercise capacity [ Time Frame: 3 months ] [ Designated as safety issue: No ]
- Endothelial function, oxygen kinetics, ventilatory drive [ Time Frame: 3 months ] [ Designated as safety issue: No ]
|Study Start Date:||November 2004|
|Estimated Study Completion Date:||September 2013|
|Primary Completion Date:||April 2010 (Final data collection date for primary outcome measure)|
Active Comparator: Combined interval and strength training
CHF Pts randomly designed at the combined interval and strength training group
Other: Exercise training
Interval training (30 sec 50% of peak Work Rate achieved at the steep ramp test/60 sec recovery no exercise) for 20 min and Strength training of the quadriceps, hamstrings, muscles of the shoulder and biceps brachialis for 20 min 3 times per week for 36 sessions
Active Comparator: Aerobic interval training
CHF Patients that randomly designed to participate at the interval training group
Other: Exercise training
Interval training (30 sec 50% of peak Work Rate achieved at the steep ramp test/60 sec recovery no exercise) for 40 min in the interval training group
|Cardiopulmonary Exercise Testing & Rehabilitation Laboratory, First Critical Care Unit, School of Medicine, National & Kapodistrian University of Athens|
|Athens, Greece, 10676|
|Principal Investigator:||Serafim Nanas, MD||University of Athens|