Inclusion Criteria:

1. Males and females ≥ 18 to 60 years of age.
2. HIV infection.
3. Stable ART regimen for ≥ 3 months prior to Screening.
4. HIV VL level ≤ 400 copies/mL for ≥ 2 months prior to Screening.
5. HIV VL level ≤ 50 copies/mL at Screening.
6. CD4+ T cell count ≥ 450 cells/mm3 at Screening.
7. Pre-ART nadir CD4+ T cell counts ≥ 200 cells/mm³.
8. Availability of an adequate sample of frozen plasma most recently collected (no more than 90 days and preferably within 30 days) before starting ART.
9. Laboratory values within pre-defined limits at Screening and Eligibility.
10. Negative serum pregnancy test at Screening and Eligibility for females with reproductive potential, and agreement of all subjects to use a reliable form of contraception during the study and for 12 weeks after the last dose of study drug.
11. Able and willing to give adequate written informed consent, to communicate effectively with study personnel, and willing to be compliant with protocol requirements.

Exclusion Criteria:

1. HIV-2 antibody positive at Screening Visit.
2. Positive hepatitis B surface antigen (HBsAg) or hepatitis C virus (HCV) antibody (if positive HCV antibody, HCV RNA must be negative).
3. Untreated syphilis infection (positive rapid plasma reagin [RPR]).
4. Changes in ART regimen due to virologic breakthrough.
5. History of lymph node irradiation or dissection.
6. Prior use of any HIV immunotherapy or vaccine within 9 months prior to Screening.
7. Prior participation in an AGS-004 clinical study.
8. Treatment interruption of ART for > 1 month since starting the ART from which the pre-ART plasma sample was drawn.
9. Any acute infection or medical illness within 14 days prior to Screening and throughout the pre-treatment evaluation phase (Step 1).
10. Initiation of ART during the acute HIV infection stage, if date of infection known (acute infection defined as < 6 months between date of HIV infection and ART start date).
11. Pregnancy or breast-feeding.
12. Receipt of any immune modulators or suppressors within 30 days prior to Screening and throughout the pre-treatment evaluation phase (Step 1).

13. Evidence of hepatic decompensation in cirrhotic subjects: history of ascites, hepatic encephalopathy, or bleeding esophageal varices, or screening laboratory results of any of the following:

    • International Normalized Ratio (INR) of ≥ 1.5 X upper limit of normal (ULN);
    • Serum albumin < 3.3 g/dL;
    • Serum total bilirubin > 1.8 X ULN, unless history of Gilbert's disease or deemed related to treatment with atazanavir.
14. History or other clinical evidence of significant or unstable cardiac disease (e.g., angina, congestive heart failure, recent myocardial infarction, significant arrhythmia) or clinically significant electrocardiogram (ECG) abnormalities.
15. History of moderate or severe renal impairment (i.e., persistent history of creatinine clearance < 50 mL/min) or any other renal disorder deemed clinically significant by the investigator.
16. Prior history of an acquired immunodeficiency syndrome (AIDS) defining condition.
17. History or other evidence of severe illness, malignancy, immunodeficiency other than HIV, or any other condition that would make the subject unsuitable for the study in the opinion of the investigator.
18. Known allergy or sensitivity to the components of the investigational immunotherapy.
19. Active drug or alcohol use or dependence that would interfere with adherence to study requirements in the opinion of the investigator.
20. Use of systemic corticosteroids and use of topical steroids over a total area exceeding 15 cm² within 30 days prior to Screening.
21. Any investigational antiretroviral agents or use of a CCR5 inhibitor at Screening.
22. Active autoimmune disease or condition.
23. Participation in another investigational clinical study within the previous 30 days or use of investigational agents.
24. Body weight less than 30 kg.