Sensory-cognitive and Physical Fitness Training in Mild Cognitive Impairment

This study has been completed.
University of Ulm
Information provided by (Responsible Party):
Iris-Tatjana Kolassa, University of Ulm Identifier:
First received: February 2, 2010
Last updated: November 26, 2013
Last verified: November 2013

Age-related cognitive decline is unavoidable. However, recent results of neuroplasticity-based research show that neuroplasticity-based training and physical activity might have the potential to decelerate or even reverse effects of aging and age-related cognitive impairments. Little is known whether these results also apply to pathological processes of aging such as mild cognitive impairment (MCI) and dementia.

This multi-center study aims at investigating efficiency and feasibility of a neuroplasticity-based auditory discrimination training and a physical fitness training for patients suffering from mild cognitive impairment or mild Alzheimer's disease (Mini Mental State Examination, MMSE > 21). Evaluation will include neuropsychological testing, electroencephalography (EEG) and magnetic resonance imaging (MRI) measurements as well as blood and liquor analyses.

Condition Intervention
Mild Cognitive Impairment (MCI)
Mild Alzheimer's Disease
Other: auditory discrimination training
Other: physical movement training

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Computer-based Sensory-cognitive and Physical Fitness Training in Mild Cognitive Impairment (MCI) and Mild Alzheimer's Disease (AD)

Resource links provided by NLM:

Further study details as provided by University of Konstanz:

Primary Outcome Measures:
  • Alzheimer's Disease Assessment Scale, Cognitive Subscale (ADAS-Cog) [ Time Frame: pre, post, 3-month follow-up ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • electrophysiological, blood and liquor correlates [ Time Frame: pre, post, 3-month follow-up ] [ Designated as safety issue: No ]

Estimated Enrollment: 100
Study Start Date: August 2009
Study Completion Date: March 2013
Primary Completion Date: March 2013 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: sensory-cognitive training Other: auditory discrimination training
10-week neuroplasticity-based training (5 days/week, 1 hour each, PC-based), training at home
Experimental: physical fitness Other: physical movement training
10-week training, small groups (2 days/week, 1 hour each) plus homework (3 days/week)
No Intervention: waiting list (control group)


Ages Eligible for Study:   55 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • focus: subjective and/or objective memory complaints with MMSE > 21 (MCI or mild Alzheimer's Disease, with stable medication for at least 3 months)
  • mild to moderate depression
  • corrected-to-normal hearing and vision
  • for MRI: non-magnetic metals inside the body
  • right handedness preferred

Exclusion Criteria:

  • cognitive impairment/ dementia with MMSE < 22, severe psychiatric or neurological disease (current and lifetime)
  • physical health that does not allow physical fitness tests and trainings
  • benzodiazepin, tricyclic antidepressants
  • for MRI: magnetic metal inside the body, cardiac pacemaker etc.
  • for liquor: insufficient blood coagulation, insufficient brain pressure
  Contacts and Locations
Please refer to this study by its identifier: NCT01061489

University of Konstanz
Konstanz, Germany, 78457
University of Ulm, Memory Clinic
Ulm, Germany, 89070
Sponsors and Collaborators
University of Konstanz
University of Ulm
Study Chair: Iris-Tatjana Kolassa, Prof. Dr. Clinical and Biological Psychology, University of Ulm
  More Information

Additional Information:
No publications provided

Responsible Party: Iris-Tatjana Kolassa, Prof. Dr. Iris-Tatjana Kolassa, University of Ulm Identifier: NCT01061489     History of Changes
Other Study ID Numbers: WIN-Kol-09
Study First Received: February 2, 2010
Last Updated: November 26, 2013
Health Authority: Germany: Ethics Commission

Keywords provided by University of Konstanz:
Mild Cognitive Impairment (MCI)
sensory-cognitive training
physical fitness

Additional relevant MeSH terms:
Alzheimer Disease
Cognition Disorders
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases
Neurodegenerative Diseases
Delirium, Dementia, Amnestic, Cognitive Disorders
Mental Disorders processed this record on April 16, 2014