The Effects of Joint Effusion on Proprioception

This study has been completed.
Sponsor:
Information provided by:
The Catholic University of Korea
ClinicalTrials.gov Identifier:
NCT01060215
First received: January 28, 2010
Last updated: February 1, 2010
Last verified: January 2010
  Purpose

The purpose of this study is to assess the effects of joint effusion on proprioceptive status in patients with knee osteoarthritis (OA).


Condition Intervention
Osteoarthritis
Procedure: Normal saline

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Official Title: Clinical Trial for the Effects of Joint Effusion on Proprioception

Resource links provided by NLM:


Further study details as provided by The Catholic University of Korea:

Primary Outcome Measures:
  • Proprioceptive acuity in Knee Joint. Proprioceptive acuity (difference between the knee angles at the target and reproduced positions) was assessed by active repositioning of the lower limb after injection or no injection. [ Time Frame: within one hour after intervention ] [ Designated as safety issue: No ]

Enrollment: 40
Study Start Date: May 2009
Study Completion Date: January 2010
Primary Completion Date: January 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: Infusion
20cc saline infusion into the knee joint
Procedure: Normal saline
20 cc normal saline injection into the knee joint
Other Name: Normal saline
No Intervention: No infusion Procedure: Normal saline
20 cc normal saline injection into the knee joint
Other Name: Normal saline

Detailed Description:

Proprioception is a sensory modality that provides feedback on the internal status of the body and enables us to perceive joint position and motion.

Osteoarthritis (OA), also called degenerative joint disease, is a major musculoskeletal condition characterized by loss of articular cartilage that leads to pain and loss of function. The most commonly affected joint is the knee, and OA may result in changes that affect not only intracapsular tissues, but also periarticular tissues, such as ligaments, capsules, tendons, and muscles. Many studies have examined the proprioceptive status of knee OA, and subjects with knee OA are known to have impaired proprioception compared with age-matched controls.

Joint effusion is a common symptom associated with chronic degenerative joint condition, but the effects of effusion on knee joint proprioception have not been investigated in detail.

A volume of 20 mL of normal saline was injected into the knee joint cavity of subjects in the experimental group under ultrasonographic guidance. Proprioceptive acuity was assessed by active repositioning of the lower limb using an electrogoniometer to measure knee joint position sense (JPS) under both non-weight-bearing and weight-bearing conditions twice, with a 20-min rest interval.

  Eligibility

Ages Eligible for Study:   50 Years and older
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

Or at least two of criteria 2-6 established by the American College of Rheumatology (ACR):

  1. Kellgren and Lawrence (K/L) grade ≥II
  2. morning stiffness <30 min in duration
  3. crepitus on movement of the knee joint
  4. bony tenderness at the knee joint margins
  5. palpable or visible bony enlargement
  6. no palpable warmth.

Exclusion Criteria:

  1. the presence of knee joint effusion determined by ultrasonography
  2. a history of knee injury or surgery
  3. a history of knee injection within 3 months
  4. a history of inflammatory arthritis
  5. taking anticoagulants
  6. balance or gait disturbance
  7. diabetes mellitus.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01060215

Locations
Korea, Republic of
Seoul St. Mary's Hospital
Seoul, Korea, Republic of, 137-701
Sponsors and Collaborators
The Catholic University of Korea
Investigators
Study Chair: Jongin Lee, M.D Department of Rehabilitation Medicine, Seoul St. Mary's Hospital
  More Information

Additional Information:
No publications provided by The Catholic University of Korea

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: JongIn Lee/Department of Rehabilitation Medicine,, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea
ClinicalTrials.gov Identifier: NCT01060215     History of Changes
Other Study ID Numbers: 52008B000100044
Study First Received: January 28, 2010
Last Updated: February 1, 2010
Health Authority: Korea: Institutional Review Board

Keywords provided by The Catholic University of Korea:
effusion
osteoarthritis
knee

Additional relevant MeSH terms:
Osteoarthritis
Hydrarthrosis
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases

ClinicalTrials.gov processed this record on October 01, 2014