Effects of Caffeine on Methacholine Challenge and Exhaled Nitric Oxide Levels.

This study has been completed.
Sponsor:
Information provided by:
University of Saskatchewan
ClinicalTrials.gov Identifier:
NCT01057875
First received: January 26, 2010
Last updated: October 5, 2010
Last verified: October 2010
  Purpose

To investigate whether or not the ingestion of caffeine with alter airway responsiveness to methacholine and/or change the level of exhaled nitric oxide.


Condition Intervention
Asthma
Other: caffeine
Other: No caffeine

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Single Blind (Subject)
Primary Purpose: Treatment
Official Title: The Effects of Caffeine on Exhaled Nitric Oxide Levels and Methacholine PC20

Resource links provided by NLM:


Further study details as provided by University of Saskatchewan:

Primary Outcome Measures:
  • methacholine pc20 [ Time Frame: 1 hour post ingestion ] [ Designated as safety issue: No ]

Estimated Enrollment: 15
Study Start Date: January 2010
Study Completion Date: February 2010
Primary Completion Date: February 2010 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: coffee with caffeine Other: caffeine
Starbuck's Grande Pike Roast coffee
Placebo Comparator: decaffeinated coffee
Starbuck's Grande Pike Roast Decaf
Other: No caffeine
Starbuck's Grande Pike Roast Decaffeinated Coffee

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • clinical diagnosis of asthma
  • FEV1 greater than 65%

Exclusion Criteria:

  • asthma is poorly controlled
  • presence of other airway disease (e.g. COPD)
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01057875

Locations
Canada, Saskatchewan
University of Saskatchewan
Saskatoon, Saskatchewan, Canada, S7N 0W8
Sponsors and Collaborators
University of Saskatchewan
Investigators
Principal Investigator: Donald W Cockcroft, MD University of Saskatchewan
  More Information

No publications provided by University of Saskatchewan

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Donald Cockcroft, MD, University of Saskatchewan
ClinicalTrials.gov Identifier: NCT01057875     History of Changes
Other Study ID Numbers: BIO REB 09-186
Study First Received: January 26, 2010
Last Updated: October 5, 2010
Health Authority: Canada: Ethics Review Committee

Additional relevant MeSH terms:
Caffeine
Nitric Oxide
Central Nervous System Stimulants
Physiological Effects of Drugs
Pharmacologic Actions
Central Nervous System Agents
Therapeutic Uses
Phosphodiesterase Inhibitors
Enzyme Inhibitors
Molecular Mechanisms of Pharmacological Action
Purinergic P1 Receptor Antagonists
Purinergic Antagonists
Purinergic Agents
Neurotransmitter Agents
Bronchodilator Agents
Autonomic Agents
Peripheral Nervous System Agents
Anti-Asthmatic Agents
Respiratory System Agents
Free Radical Scavengers
Antioxidants
Endothelium-Dependent Relaxing Factors
Vasodilator Agents
Cardiovascular Agents
Gasotransmitters
Protective Agents

ClinicalTrials.gov processed this record on September 16, 2014