The Cyclocapnic Method for Measurement of Chemosensitivity
Recruitment status was Recruiting
We aim to test our method for measuring chemosensitivity (the ventilatory response to a change in carbon dioxide), which uses sinusoidal carbon dioxide stimuli.
- Carbon dioxide sensitivity is dependent on the cycle time over which we administer the gas (frequency).
- Chemoreflex gain decreases as deadspace increases.
|Study Design:||Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
|Official Title:||Developing an Improved Measure of Chemosensitivity for the Study of Periodic Breathing in Heart Failure: the Cyclocapnic Method|
- Chemoreflex gain as measured by cyclocapnic method [ Time Frame: every minute ] [ Designated as safety issue: No ]
|Study Start Date:||January 2008|
|Estimated Study Completion Date:||October 2010|
|Estimated Primary Completion Date:||April 2010 (Final data collection date for primary outcome measure)|
Other: carbon dioxide
We will apply a new method for the measurement of chemosensitivity (how sensitive a person is to changes in carbon dioxide), which is one of the principle determinants of whether people with heart failure develop abnormal breathing patterns We have shown in a pilot study that administering sinusoidal patterns of inspired carbon dioxide produces similar sinusoidal responses in ventilation. We aim to test our method for measuring chemosensitivity, which uses sinusoidal carbon dioxide stimuli (similar to those that drive the oscillations in ventilation found in periodic breathing). We aim to show that how the cycle time of carbon dioxide administered affects the resulting ventilatory oscillations and therefore that when measuring the chemoreflex clinically, it is important to deliver carbon dioxide stimuli that replicate the cycle time of oscillations in carbon dioxide seen in periodic breathing (typically approximately one minute).
|Contact: Darrel P Francis, MD||+44 207 594 firstname.lastname@example.org|
|St Mary's Hospital||Recruiting|
|London, United Kingdom, W2 1LA|
|Contact: Resham Baruah, MB BS 020 75941027 email@example.com|
|Contact: Darrel P Francis, MD +44 207 594 1093 firstname.lastname@example.org|
|Principal Investigator:||Darrel P Francis, MD||Imperial College London|