Family-based Genetic Long-term Study of Brain Function in Schizophrenia (FamilySchizo)

The recruitment status of this study is unknown because the information has not been verified recently.
Verified January 2010 by Taichung Veterans General Hospital.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Taichung Veterans General Hospital
ClinicalTrials.gov Identifier:
NCT01045824
First received: January 6, 2010
Last updated: January 14, 2010
Last verified: January 2010
  Purpose

The goal of this research is to find out possible susceptible gene(s) in schizophrenic patients with family history and 5-year period functional changes of brain among the members of family, in order to further analysis factors and their interactions.


Condition
Schizophrenia
Blooddraw
MRI

Study Type: Observational
Study Design: Observational Model: Family-Based
Official Title: The Genetic Study of Longitudinal Brain Function Among Schizophrenic Patients With Family History

Resource links provided by NLM:


Further study details as provided by Taichung Veterans General Hospital:

Biospecimen Retention:   Samples With DNA

10-20cc of blood will be drawn for DNA analysis


Estimated Enrollment: 600
Study Start Date: January 2008
Estimated Study Completion Date: January 2014
Estimated Primary Completion Date: January 2014 (Final data collection date for primary outcome measure)
Detailed Description:

Schizophrenia is a serious mental disease, highly family inheritable inclination. By means of traditional psychiatry diagnosis, genetics and long term brain change researches will help to unveil the secret of schizophrenia and other factors. The advantage of comparative gene hybridization is that chromosome copy number alterations can be detected; this technique has been widely applied in many researches, such as cancer, mental retardation screening and autism. As we known, we are the first one use this technique in chromosome abnormality research for family history schizophrenic patient, this study also is the first one to track the relationship of long term brain function alteration and chromosome abnormality in Taiwan.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Schizophrenia family

Criteria

Inclusion Criteria:

1.Psychiatry doctor diagnosed who met the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) criteria for schizophrenia or schizoaffective disorder, family history, age older than 15 will be recruited for participation in this study. Participants agree and sign informed consent forms will eligible to participate this experiment.

2.10-20c.c blood will be drawn from the participants. 3.Participants need to understand procedures and assays of this experiment. 4.At least one psychiatry doctor interview needed, participants and their family voluntarily join this interview, approximately 30-45min.

Exclusion Criteria:

  1. Participant can not understand procedures and assays of this experiment.
  2. Participant has another major mental disease other than the inclusion criteria.
  3. Participant has material abuse history, it could seriously influence diagnosis.
  4. Participant has combination diseases, it could seriously influence diagnosis.
  5. Psychopathy or psychosis can not be categorized in defined group.

Other considerations:

  1. Participants, age fewer than 20 needs to their deputy guardians (parents) and their own consent altogether.
  2. Participants who are inability needs to their deputy guardians (parents) and their own consent altogether.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01045824

Contacts
Contact: Tsuo-Hung Lan, MD., PhD. 04-23592525 ext 3460 tosafish@hotmail.com
Contact: Chin Cheng, MD. 0966213994 ccchinnn@gmail.com

Locations
Taiwan
Taichung Veterans General Hospital Recruiting
Taichung City, Taiwan, 40705
Contact: Tsuo-Hung Lan, MD., PhD.    886-4-23592525 ext 3460    tosafish@hotmail.com   
Contact: Chin Cheng, MD.    0966-213994    ccchinnn@gmail.com   
Sub-Investigator: Chin Cheng, MD.         
Sponsors and Collaborators
Taichung Veterans General Hospital
Investigators
Study Director: Tsuo-Hung Lan, MD., PhD. Taichung Veterans General Hospital
Study Director: Tsuo-Hung Lan, MD.,PhD Taichung Veterans General Hospital
  More Information

No publications provided

Responsible Party: IRB TCVGH, Taichung Veterans General Hospital
ClinicalTrials.gov Identifier: NCT01045824     History of Changes
Other Study ID Numbers: C08202
Study First Received: January 6, 2010
Last Updated: January 14, 2010
Health Authority: Taiwan: Institutional Review Board

Keywords provided by Taichung Veterans General Hospital:
Schizophrenia
DNA
MRI

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia and Disorders with Psychotic Features
Mental Disorders

ClinicalTrials.gov processed this record on September 30, 2014