Cognitive Function in Elderly Marathon Runners (APSOEM)
There is substantial research on the effects of physical exercise on cognitive functions. However, less attention has been paid on the requirements of training intensity and length to enhance cognitive abilities in the elderly. To the investigators knowledge no studies have evaluated the effects of extensive endurance exercise training on cognitive functions by studying elderly marathon runners and bicyclists. On the basis of the scientific literature published so far it is not known whether the beneficial impact of endurance exercise training depends on the intensity of training.
The investigators therefore designed a cohort study with adequate power in order to evaluate the effects of intensive endurance exercise training on cognition. This trial, an Austrian prospective cohort study in cognitive function of elderly marathon-runners (APSOEM) is being conducted and will compare neuropsychological performance outcomes of elderly marathon runners or bicyclists with controls matched concerning age, education years, occupation, and verbal intelligence.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Austrian Prospective Cohort Study in Cognitive Function of Elderly Marathon-runners|
- the proportion of subjects, who will develop mild cognitive impairment [ Time Frame: 5 years ] [ Designated as safety issue: No ]
- impairment in the neurocognitive performance scores [ Time Frame: 5 years ] [ Designated as safety issue: No ]Neuropsychological testing and Questionnaires The Vienna Neuropsychological Test Battery (VNTB) as well as the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) were selected in order to assess cognitive functions, such as visuo-construction, concentration/attention, language, memory and executive functioning domains. These cognitive abilities are known to be commonly affected by Alzheimer's Disease and other dementias. The two batteries of tests have been found sensitive in the evaluation of mild cognitive impairment
- brain-derived neurotrophic factor (BDNF) [ Time Frame: 5 years ] [ Designated as safety issue: No ]
- Apo e4 carrier state [ Time Frame: 5 years ] [ Designated as safety issue: No ]
- self rating by questionnaires [ Time Frame: 5 years ] [ Designated as safety issue: No ]The following self rating scales were used: premorbid intelligence level, subjective memory functions, psychological and physiological well-being, depression and activities of daily living. To assess positive health practices a German Version of the validated Personal Lifestyle Questionnaire (PLQ) was used.
- insulin-like growth factor (IGF-1) [ Time Frame: 5 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Apolipoprotein E4 genotype, Insulin-like growth factor-1, Brain-derived neurotrophic factor, rs6265-Genotype
|Study Start Date:||December 2008|
|Estimated Study Completion Date:||February 2014|
|Estimated Primary Completion Date:||February 2014 (Final data collection date for primary outcome measure)|