Cognitive Function in Elderly Marathon Runners (APSOEM)

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborator:
National Bank of Austria
Information provided by (Responsible Party):
Robert Winker, Medical University of Vienna
ClinicalTrials.gov Identifier:
NCT01045031
First received: January 7, 2010
Last updated: January 3, 2014
Last verified: January 2014
  Purpose

There is substantial research on the effects of physical exercise on cognitive functions. However, less attention has been paid on the requirements of training intensity and length to enhance cognitive abilities in the elderly. To the investigators knowledge no studies have evaluated the effects of extensive endurance exercise training on cognitive functions by studying elderly marathon runners and bicyclists. On the basis of the scientific literature published so far it is not known whether the beneficial impact of endurance exercise training depends on the intensity of training.

The investigators therefore designed a cohort study with adequate power in order to evaluate the effects of intensive endurance exercise training on cognition. This trial, an Austrian prospective cohort study in cognitive function of elderly marathon-runners (APSOEM) is being conducted and will compare neuropsychological performance outcomes of elderly marathon runners or bicyclists with controls matched concerning age, education years, occupation, and verbal intelligence.


Condition
Exercise Training
Cognitive Function

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Austrian Prospective Cohort Study in Cognitive Function of Elderly Marathon-runners

Resource links provided by NLM:


Further study details as provided by Medical University of Vienna:

Primary Outcome Measures:
  • the proportion of subjects, who will develop mild cognitive impairment [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  • impairment in the neurocognitive performance scores [ Time Frame: 5 years ] [ Designated as safety issue: No ]
    Neuropsychological testing and Questionnaires The Vienna Neuropsychological Test Battery (VNTB) as well as the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) were selected in order to assess cognitive functions, such as visuo-construction, concentration/attention, language, memory and executive functioning domains. These cognitive abilities are known to be commonly affected by Alzheimer's Disease and other dementias. The two batteries of tests have been found sensitive in the evaluation of mild cognitive impairment


Secondary Outcome Measures:
  • brain-derived neurotrophic factor (BDNF) [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  • Apo e4 carrier state [ Time Frame: 5 years ] [ Designated as safety issue: No ]
  • self rating by questionnaires [ Time Frame: 5 years ] [ Designated as safety issue: No ]
    The following self rating scales were used: premorbid intelligence level, subjective memory functions, psychological and physiological well-being, depression and activities of daily living. To assess positive health practices a German Version of the validated Personal Lifestyle Questionnaire (PLQ) was used.

  • insulin-like growth factor (IGF-1) [ Time Frame: 5 years ] [ Designated as safety issue: No ]

Biospecimen Retention:   Samples With DNA

Apolipoprotein E4 genotype, Insulin-like growth factor-1, Brain-derived neurotrophic factor, rs6265-Genotype


Estimated Enrollment: 136
Study Start Date: December 2008
Estimated Study Completion Date: February 2014
Estimated Primary Completion Date: February 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts
Marathon runners
marathon bicyclists
Controls

  Eligibility

Ages Eligible for Study:   60 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Marathon runners, bicyclists and controls from the greater Vienna area

Criteria

Inclusion Criteria:

  • Current Marathon runners or marathon bicyclists and controls from the greater Vienna area

Exclusion Criteria:

  • Current of past neurotoxic exposure
  • Not German as native language
  • Diseases, that might affect central nervous system (stroke, meningitis, meningeoma, hydrocephalus,..)
  • Manifest cardiovascular disease
  • Alcoholism
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

No publications provided by Medical University of Vienna

Additional publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: Robert Winker, Ass. Prof., Medical University of Vienna
ClinicalTrials.gov Identifier: NCT01045031     History of Changes
Other Study ID Numbers: Grant Project number 12979
Study First Received: January 7, 2010
Last Updated: January 3, 2014
Health Authority: Austria: Ethikkommission

Keywords provided by Medical University of Vienna:
to evaluate the effects of intensive endurance exercise training on cognitive function by means of the CERAD-test battery

ClinicalTrials.gov processed this record on October 16, 2014