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Trial record 3 of 3 for:    Open Studies | "Pericarditis"

ST Elevation in Acute Chest Pain; Could Measurement of Lipoprotein-associated Phospholipase A2 (Lp-PLA2) be Helpful to the Clinician?

The recruitment status of this study is unknown because the information has not been verified recently.
Verified June 2011 by Wolfson Medical Center.
Recruitment status was  Recruiting
Sponsor:
Information provided by:
Wolfson Medical Center
ClinicalTrials.gov Identifier:
NCT01041339
First received: December 30, 2009
Last updated: August 16, 2011
Last verified: June 2011
  Purpose

A blood test (2-3 cc peripheral venous blood) drawn /used from already available required lab tests to distinguish between pericarditis accompanied with electrocardiogram (ECG) signs mimicking infarction. A test of clinical potential if proven to be able to support either origin of acute chest pain etiology.


Condition
Acute Chest Syndrome

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: ST Elevation (Acute Coronary Syndrome Versus Pericarditis;Could Measurement of Lp-associated PLA2 -a Vascular Specific Marker of Inflammation- be Helpful to the Clinician?

Resource links provided by NLM:


Further study details as provided by Wolfson Medical Center:

Biospecimen Retention:   Samples Without DNA

plasma kept in -80 celsius refrigerator


Estimated Enrollment: 100
Study Start Date: January 2010
Estimated Study Completion Date: January 2012
Estimated Primary Completion Date: November 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
acute chest pain ST elevation
patients admitted with acute chest pain sharing ST elevation in ER-ECG and elevated troponin
controls
asymptomatic patients

Detailed Description:

Too many times young patients presenting with acute chest pain are referred to invasive angiography or treated with anticoagulation therapy a measure of detrimental effect in those inflicted with acute pericarditis.

A simple blood test (the PLAC test) may have some value in aiding rapid diagnosis saving need for cath.

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

acute chest pain patients admitted to ICCU with acute ST elevation and elevated troponin

Criteria

Inclusion Criteria:

  • acute chest pain
  • acute ST elevation
  • elevated troponin I

Exclusion Criteria:

  • patients with recent (> 24 hour chest pain) myocardial infarction
  • refusing to provide blood samples
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01041339

Contacts
Contact: alexander J izhaki, MD 0508916027 alex.izhaki@gmail.com
Contact: yoseph rozenmam, MD 97235028404 rozenman@wolfson.health.gov.il

Locations
Israel
The E.Wolfson MC Recruiting
Holon, Israel, 52100
Contact: alexander J izhaki, MD    972-3-5028333    alex.izhaki@gmail.com   
Principal Investigator: alexander J izhaki, MD         
Sponsors and Collaborators
Wolfson Medical Center
Investigators
Principal Investigator: Alexander J Izhaki, MD The E.Wolfson MC
  More Information

Additional Information:
No publications provided

Responsible Party: Alexander Izhaki MD, Heart Institute , The E. Wolfson MC
ClinicalTrials.gov Identifier: NCT01041339     History of Changes
Other Study ID Numbers: 0075-09-WOMC
Study First Received: December 30, 2009
Last Updated: August 16, 2011
Health Authority: Israel: Ethics Commission

Keywords provided by Wolfson Medical Center:
LpPLA2
ST elevation
acute pericarditis

Additional relevant MeSH terms:
Acute Chest Syndrome
Syndrome
Anemia
Anemia, Hemolytic
Anemia, Hemolytic, Congenital
Anemia, Sickle Cell
Disease
Genetic Diseases, Inborn
Hematologic Diseases
Hemoglobinopathies
Lung Diseases
Pathologic Processes
Respiration Disorders
Respiratory Tract Diseases

ClinicalTrials.gov processed this record on November 20, 2014