Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

This study is currently recruiting participants. (see Contacts and Locations)
Verified March 2014 by National Institutes of Health Clinical Center (CC)
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT01036581
First received: December 18, 2009
Last updated: April 9, 2014
Last verified: March 2014
  Purpose

Background:

- Functional and structural magnetic resonance imaging (MRI) techniques have allowed researchers to map and study how the brain works when at rest and when engaged in specific tasks. MRI scans have provided more information about how drugs affect the brain, and about how drug addiction changes the brain and influences behavior, mood, and thinking processes. To better understand the underlying mechanism of drug addiction and to develop strategies for more effective treatment, researchers are interested in developing new MRI techniques to study the effects of addiction on the brain.

Objectives:

- To develop new functional and structural MRI techniques, and to evaluate their potential use in brain imaging studies related to addiction.

Eligibility:

  • Individuals between 18 and 50 years of age.
  • Participants may be smokers or nonsmokers, and may use drugs or not use drugs.

Design:

  • During the initial screening, participants will complete questionnaires about family and personal history, drug use, and other information as required by the researchers. Participants who will be asked to complete tasks during the MRI scan will be shown how to perform these tasks before the scanning session.
  • Before each study session, participants may be asked to complete some or all of the following: questions about their drug use during the last week, a breathalyzer test, a urine drug-use assessment, a urine pregnancy test, or a measure of carbon monoxide. Participants will also provide blood samples before the start of the scan.
  • For each scanning session, participants will have an MRI scan that will last approximately 2 hours.
  • MRI scans may include injections with a contrast agent to study brain function, specific tasks to be performed during the scan, or an experiment that studies the brain's response to carbon dioxide.

Condition
Drug Abuse
Nicotine Dependence

Study Type: Observational
Official Title: Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 600
Study Start Date: July 2003
Detailed Description:

Objective:

Functional and structural magnetic resonance imaging techniques have proven essential for noninvasive mapping of brain physiology and pathology. The primary objective of this protocol is to develop advanced magnetic resonance imaging and spectroscopy (MRI and MRS) techniques for neuroimaging studies related to addiction. These neuroimaging techniques will be used in other studies to better understand the underlying mechanism of drug addiction and to potentially develop strategies for more effective treatment.

Study population:

Healthy controls and drug users will participate in the study. Technical developments of MRI/MRS will be performed on healthy controls, while the evaluation of the applicability of these techniques to addiction related neuroimaging studies will be performed using drug users and healthy controls.

Design:

Based on the fundamental principle of the biophysical transduction of physiological signals to magnetic resonance (MR) imaging and spectroscopic signals, advanced techniques will be developed to measure the activity, metabolism, structure, and biochemistry of the brain. The development of these techniques typically includes the following steps: 1) proof-of-concept computer simulations, 2) implementation of the imaging concept with an MRI scanner and phantoms, 3) feasibility testing on control subjects, and 4) evaluation of the sensitivity and specificity of these techniques in detecting functional and/or structural alterations of the brain related to a specific disease.

Outcome measures:

Advanced neuroimaging techniques developed from this protocol will demonstrate the ability to distinguish between drug using and control populations. Successful techniques will then be incorporated into hypothesis driven studies in the Neuroimaging Research Branch at NIDA-IRP. These techniques will also be useful, through publications and technology transfer, to the entire neuroimaging society.

  Eligibility

Ages Eligible for Study:   18 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria
  • Subjects must be between the ages of 18-50, be generally healthy and male or non-pregnant female. Smokers, non-smokers, drug using and non-drug using populations will participate in this study.

INCLUSION CRITERIA:

General:

  • Male and non-pregnant female adults between the ages of 18-50.
  • All subjects must be able to provide informed consent.

EXCLUSION CRITERIA:

Subjects will be excluded if they:

  • Are pregnant. Urine pregnancy tests will be performed on all female volunteers of child-bearing potential before each experimental session.
  • Are unable to undergo MRI scanning due to implanted metallic devices (cardiac pacemaker or neurostimulator, some artificial joints, metal pins, surgical clips or other implanted metal parts including Copper 7 IUD) or claustrophobia.
  • Have major medical illnesses to include, but not limited to, hypertension, cardiovascular disease, asthma, diabetes, peripheral vascular diseases, coagulopathies, syncope, history of superficial or deep vein thrombosis, HIV, or other clinically significant infectious diseases that may alter the signal being measured.
  • Have current major psychiatric disorders to include, but not limited to, mood, anxiety, psychotic disorders.
  • Have neurological illnesses including, but not limited to, seizure disorders, migraine, multiple sclerosis, movement disorders, or history of head trauma, CVA, CNS tumor.
  • Have cognitive impairment as assessed by screening WASI vocabulary subtest below 48, corresponding to full IQ of 85 (in that case on screening, a full WASI will be done to verify IQ of 85 or above). Justification: Cognitive impairment and learning disabilities are associated with alterations in brain regions used to accomplish tasks, and, therefore, may introduce significant variably into the data.
  • Inability to comply with task demands.

Additional exclusions for some experiments:

Based on the scientific and medical requirements of the particular experiment, participants may also be excluded for:

  • left-handedness (if using a cognitive or affective task),
  • color-blindness (if using a task requiring color discrimination),
  • drug use diagnosis (if a technique is being validated in a non-drug using population),
  • renal insufficiency (if contrast agents are to be used), as determined by estimated glomerular filtration rate, which must be > 60 ml/min, as renal insufficiency greatly increases the risk of nephrogenic systemic fibrosis from gadolinium exposure. Renal insufficiency may also be associated with metabolic abnormalities that may interfere with MR imaging.
  • Lactation (if contrast agents are to be used). The safety of gadolinium for nursing infants has not been established.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01036581

Contacts
Contact: Yihong Yang, Ph.D. (443) 740-2648 yihongyang@mail.nih.gov

Locations
United States, Maryland
National Institute on Drug Abuse, Biomedical Research Center (BRC) Recruiting
Baltimore, Maryland, United States, 21224
Contact: For more information contact Mathew's Media Group Recruiting    800-535-8254    researchstudies@mail.nih.gov   
Sponsors and Collaborators
Investigators
Principal Investigator: Yihong Yang, Ph.D. National Institute on Drug Abuse (NIDA)
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT01036581     History of Changes
Other Study ID Numbers: 999903380, 03-DA-N380
Study First Received: December 18, 2009
Last Updated: April 9, 2014
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Magnetic Resonance Imaging (MRI)
Functional Brain Imaging
Magnetic Resonance Spectroscopy
Diffusion Tensor Imaging
Drug Abuse

ClinicalTrials.gov processed this record on September 30, 2014