Pazopanib Hydrochloride in Treating Patients With Metastatic Urethral Cancer or Bladder Cancer That Has Relapsed or Not Responded to Treatment

This study has been completed.
Sponsor:
Information provided by:
National Cancer Institute (NCI)
ClinicalTrials.gov Identifier:
NCT01031875
First received: December 13, 2009
Last updated: August 9, 2013
Last verified: September 2012
  Purpose

RATIONALE: Pazopanib hydrochloride may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth and by blocking blood flow to the tumor.

PURPOSE: This phase II trial is studying how well pazopanib hydrochloride works in treating patients with or metastatic urothelial cancer or bladder cancer that has relapsed or not responded to treatment.


Condition Intervention Phase
Bladder Cancer
Transitional Cell Cancer of the Renal Pelvis and Ureter
Urethral Cancer
Drug: pazopanib hydrochloride
Radiation: fludeoxyglucose F 18
Phase 2

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Masking: Open Label
Primary Purpose: Treatment
Official Title: Phase 2 Study With the Multi-Targeted Tyrosine-Kinase Inhibitor Pazopanib (GW786034) for Patients With Relapsed or Refractory Urothelial Cancer

Resource links provided by NLM:


Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Response rate (complete and partial response) according to RECIST 1.1 criteria [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Safety and tolerability, in terms of incidence, nature, and severity of treatment-related adverse events according to CTCAE v4.0 [ Designated as safety issue: Yes ]
  • Progression-free survival [ Designated as safety issue: No ]

Estimated Enrollment: 41
Study Start Date: December 2009
Study Completion Date: August 2012
Primary Completion Date: December 2011 (Final data collection date for primary outcome measure)
Detailed Description:

OBJECTIVES:

Primary

  • To evaluate the activity of daily oral doses of pazopanib hydrochloride monotherapy in patients with relapsed/refractory metastatic urothelial carcinoma or transitional cell tumors.

Secondary

  • To evaluate the safety and tolerability of pazopanib hydrochloride monotherapy in a population of chemotherapy pretreated patients.
  • To assess progression-free survival of these patients.

Tertiary

  • To evaluate the ability of whole-body 18FDG-PET to image metastases and monitor tumor response and to determine the rate of concordance with CT imaging and RECIST response criteria.
  • To evaluate the relationship existing between tumor response measured by 18FDG-PET and progression-free survival.

OUTLINE: This is a multicenter study.

Patients receive oral pazopanib hydrochloride once daily on days 1-28. Treatment repeats every 28 days in the absence of disease progression or unacceptable toxicity.

Patients undergo whole-body 18FDG-PET at baseline and periodically.

After completion of study treatment, patients are followed for 2 years.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

DISEASE CHARACTERISTICS:

  • Histologically confirmed diagnosis of transitional cell tumors of the bladder or the urothelium

    • Metastatic disease
    • Relapsed or refractory disease
  • Measurable disease, defined as ≥ 1 unidimensionally measurable lesion ≥ 2 cm by conventional techniques or ≥ 1 cm by spiral CT scan
  • Must have failed ≥ 1 cisplatin-based conventional chemotherapy regimen for metastatic disease (neoadjuvant/adjuvant therapy excluded)
  • No history or clinical evidence of CNS metastases or leptomeningeal carcinomatosis, except for individuals who were previously treated for CNS metastases, are asymptomatic, and have had no requirement for steroids or anti-seizure medication for the past 6 months

PATIENT CHARACTERISTICS:

  • ECOG performance status 0-1
  • Life expectancy ≥ 12 weeks
  • Hemoglobin ≥ 9.0 g/dL
  • Absolute neutrophil count ≥ 1,000/μL
  • Platelet count ≥ 75,000/μL
  • Total bilirubin ≤ 1.5 x upper limit of normal (ULN)
  • ALT and AST ≤ 2.5 x ULN (≤ 5 x ULN for patients with liver involvement)
  • Alkaline phosphatase ≤ 4 x ULN
  • Serum creatinine ≤ 1.5 mg/dL
  • PT-INR/PTT < 1.5 x ULN
  • Not pregnant or nursing
  • Negative pregnancy test
  • Fertile patients must use effective barrier contraception during and for 3 months after completion of study therapy
  • Able to swallow oral medication
  • None of the following cardiovascular conditions within the past 6 months:

    • Cardiac angioplasty or stenting
    • Myocardial infarction
    • Unstable angina
    • Symptomatic peripheral vascular disease
    • NYHA class III or IV congestive heart failure
    • Cardiac arrhythmias requiring anti-arrhythmic therapy (beta-blockers or digoxin are permitted)
    • Uncontrolled hypertension
  • No history of HIV infection or active chronic hepatitis B or C
  • No active clinically serious infections > grade 2 NCI-CTC version 4.0
  • No seizure disorder requiring medication (e.g., steroids or anti-epileptics)
  • No history of any of the following conditions within the past 6 months:

    • Cerebrovascular accident
    • Pulmonary embolism
    • Untreated deep venous thrombosis
  • No evidence or history of bleeding diathesis
  • No known endobronchial lesions or involvement of large pulmonary vessels by tumor
  • No hemoptysis within the past 6 weeks
  • No gastrointestinal abnormalities that may increase the risk of GI bleeding or affect the absorption of investigational study drug
  • No other cancer that is distinct in primary site or histology from the cancer being evaluated in this study, except cervical carcinoma in situ, treated basal cell carcinoma, or any cancer curatively treated > 5 years prior to study entry
  • No substance abuse, medical, psychological, or social conditions that may interfere with the study participation or evaluation of the study results
  • No concurrent unstable condition that could jeopardize patient safety and their compliance in the study
  • No non-healing wound, fracture, or ulcer within the past 28 days
  • No major trauma within the past 28 days
  • No known immediate or delayed hypersensitivity reaction or idiosyncrasy to drugs chemically related to pazopanib hydrochloride

PRIOR CONCURRENT THERAPY:

  • See Disease Characteristics
  • Recovered from all prior therapy
  • At least 14 days since prior radiotherapy, except palliative radiotherapy
  • At least 14 days since tumor embolization
  • At least 14 days or 5 half-lives (whichever is longer) of a drug since prior chemotherapy, immunotherapy, biologic therapy, investigational therapy, or hormonal therapy
  • At least 3 weeks since prior biologic response modifiers (e.g., G-CSF)

    • G-CSF and other hematopoietic growth factors may be used in the management of acute toxicity (e.g., febrile neutropenia) when clinically indicated or at the discretion of the investigator, however they may not be used to avoid a required dose reduction
    • Chronic erythropoietin allowed provided no dose adjustment is undertaken within 2 months prior to the study or during the study
  • No prior pazopanib hydrochloride
  • No coronary artery by-pass graft surgery within the past 6 months
  • No major surgery within the past 28 days
  • Concurrent coumadin or heparin for therapeutic anticoagulation allowed provided that no prior evidence of underlying abnormality in PT-INR/PTT parameters exist
  • Not concurrently undergoing renal dialysis
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT01031875

Locations
Italy
Fondazione Istituto Nazionale dei Tumori
Milan, Italy, 20133
Sponsors and Collaborators
Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Investigators
Study Chair: Roberto Salvioni, MD Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Investigator: Nicola Nicolai, MD Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Investigator: Andrea Necchi, MD Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
  More Information

Publications:
ClinicalTrials.gov Identifier: NCT01031875     History of Changes
Other Study ID Numbers: ITA-MIL-IRCCS-INT-70/09, CDR0000661071, EUDRACT-2009-017093-20, EU-20990
Study First Received: December 13, 2009
Last Updated: August 9, 2013
Health Authority: Unspecified

Keywords provided by National Cancer Institute (NCI):
recurrent bladder cancer
stage IV bladder cancer
recurrent urethral cancer
distal urethral cancer
proximal urethral cancer
urethral cancer associated with invasive bladder cancer
metastatic transitional cell cancer of the renal pelvis and ureter
recurrent transitional cell cancer of the renal pelvis and ureter
stage IV urethral cancer

Additional relevant MeSH terms:
Urinary Bladder Neoplasms
Urethral Neoplasms
Carcinoma, Transitional Cell
Kidney Neoplasms
Ureteral Neoplasms
Urologic Neoplasms
Urogenital Neoplasms
Neoplasms by Site
Neoplasms
Urinary Bladder Diseases
Urologic Diseases
Urethral Diseases
Carcinoma
Neoplasms, Glandular and Epithelial
Neoplasms by Histologic Type
Kidney Diseases
Ureteral Diseases
Fluorodeoxyglucose F18
Radiopharmaceuticals
Diagnostic Uses of Chemicals
Pharmacologic Actions
Molecular Mechanisms of Pharmacological Action

ClinicalTrials.gov processed this record on July 31, 2014