Now Available for Public Comment: Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials

Chronic Alcohol and Brain Stress Circuit Response

This study is currently recruiting participants. (see Contacts and Locations)
Verified October 2013 by Yale University
Sponsor:
Collaborator:
Information provided by (Responsible Party):
Rajita Sinha, Yale University
ClinicalTrials.gov Identifier:
NCT01031264
First received: December 10, 2009
Last updated: October 27, 2013
Last verified: October 2013
  Purpose

Alcoholism is among the top three causes of preventable death and disease in the US (Mokdad et al., 2004; Room et al., 2005). Stress plays an important role in the development of alcoholism and in high vulnerability to alcohol relapse. This study will provide a greater understanding of the mechanism by which stress and alcohol consumption interacts to influence development of compulsive alcohol seeking and vulnerability to stress-induced drinking, and the results will have significant implications for the development of new prevention and treatment interventions for alcoholism.


Condition
Stress
Alcoholism

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Chronic Alcohol and Brain Stress Circuit Response

Resource links provided by NLM:


Further study details as provided by Yale University:

Primary Outcome Measures:
  • Assess differences in reactivity to cue imagery [ Time Frame: 2 years from start of study ] [ Designated as safety issue: No ]
    Physiological measures will be collected (heart rate, blood levels), self-reports of emotional states completed & alcohol taste task performed


Estimated Enrollment: 120
Study Start Date: January 2009
Estimated Study Completion Date: December 2014
Estimated Primary Completion Date: December 2014 (Final data collection date for primary outcome measure)
Groups/Cohorts
Social drinkers

  Eligibility

Ages Eligible for Study:   21 Years to 50 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

social drinkers

Criteria

Inclusion Criteria:

  • ages 21-50
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01031264

Locations
United States, Connecticut
Yale Stress Center Recruiting
New Haven, Connecticut, United States, 06519
Contact: Rachel L Hart, MS    203-737-4791    rachel.hart@yale.edu   
Principal Investigator: Rajita Sinha, PhD         
Sponsors and Collaborators
Yale University
Investigators
Principal Investigator: Rajita Sinha, PhD Yale University
  More Information

No publications provided

Responsible Party: Rajita Sinha, Professor, Yale University
ClinicalTrials.gov Identifier: NCT01031264     History of Changes
Other Study ID Numbers: 0706002821, R01AA013892
Study First Received: December 10, 2009
Last Updated: October 27, 2013
Health Authority: United States: Institutional Review Board

Keywords provided by Yale University:
social drinkers

Additional relevant MeSH terms:
Alcoholism
Alcohol-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Substance-Related Disorders

ClinicalTrials.gov processed this record on November 24, 2014