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Role of Oral Glutathione in Skin Whitening

This study has been completed.
Sponsor:
Information provided by:
Chulalongkorn University
ClinicalTrials.gov Identifier:
NCT01016080
First received: November 17, 2009
Last updated: NA
Last verified: November 2009
History: No changes posted
  Purpose

Oral and intravenous glutathione have been used widely to whiten the skin. The investigators tested this hypothesis by giving oral glutathione for 4 weeks to medical students.


Condition Intervention Phase
Skin Whitening
 Drug: glutathione
Drug: placebo
 Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Glutathione as an Oral Whitening Agent: a Randomized, Double-blind, Placebo-controlled Study

Resource links provided by NLM:

Drug Information available for: Glutathione
U.S. FDA Resources

Further study details as provided by Chulalongkorn University:

Primary Outcome Measures:
  • Skin melanin index [ Time Frame: 4 weeks ] [ Designated as safety issue: Yes ]

Enrollment: 60
Study Start Date: February 2009
Study Completion Date: June 2009
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: oral glutathione
glutathione, 500 mg, taken orally twice daily
 Drug: glutathione
250 mg capsules, twice daily, orally
Placebo Comparator: placebo capsules
identical-appearing placebo capsules
 Drug: placebo
250 mg capsules, twice daily, orally

  Eligibility

Ages Eligible for Study:   18 Years to 25 Years
Genders Eligible for Study:   Both
Criteria

Inclusion Criteria:

  • Healthy medical students

Exclusion Criteria:

  • history of skin cancer, especially melanoma
  • consumption of any preparations containing glutathione within 1 month of enrollment
  • pigmentary disorders or any dermatoses
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01016080

Locations
Thailand
King Chulalongkorn Memorial Hospital
Bangkok, Thailand, 10330
Sponsors and Collaborators
Chulalongkorn University
  More Information

No publications provided

Responsible Party: Pravit Asawanonda, Chulalongkorn University
ClinicalTrials.gov Identifier: NCT01016080     History of Changes
Other Study ID Numbers: COA840/2008
Study First Received: November 17, 2009
Last Updated: November 17, 2009
Health Authority: Thailand: Ethical Committee

Keywords provided by Chulalongkorn University:
glutathione
melanin
whitening
UV spots
skin pigment

ClinicalTrials.gov processed this record on May 23, 2013