Role of Oral Glutathione in Skin Whitening

This study has been completed.
Sponsor:
Information provided by:
Chulalongkorn University
ClinicalTrials.gov Identifier:
NCT01016080
First received: November 17, 2009
Last updated: NA
Last verified: November 2009
History: No changes posted
  Purpose

Oral and intravenous glutathione have been used widely to whiten the skin. The investigators tested this hypothesis by giving oral glutathione for 4 weeks to medical students.


Condition Intervention Phase
Skin Whitening
Drug: glutathione
Drug: placebo
Phase 1

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: Glutathione as an Oral Whitening Agent: a Randomized, Double-blind, Placebo-controlled Study

Resource links provided by NLM:


Further study details as provided by Chulalongkorn University:

Primary Outcome Measures:
  • Skin melanin index [ Time Frame: 4 weeks ] [ Designated as safety issue: Yes ]

Enrollment: 60
Study Start Date: February 2009
Study Completion Date: June 2009
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Active Comparator: oral glutathione
glutathione, 500 mg, taken orally twice daily
Drug: glutathione
250 mg capsules, twice daily, orally
Placebo Comparator: placebo capsules
identical-appearing placebo capsules
Drug: placebo
250 mg capsules, twice daily, orally

  Eligibility

Ages Eligible for Study:   18 Years to 25 Years
Genders Eligible for Study:   Both
Criteria

Inclusion Criteria:

  • Healthy medical students

Exclusion Criteria:

  • history of skin cancer, especially melanoma
  • consumption of any preparations containing glutathione within 1 month of enrollment
  • pigmentary disorders or any dermatoses
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT01016080

Locations
Thailand
King Chulalongkorn Memorial Hospital
Bangkok, Thailand, 10330
Sponsors and Collaborators
Chulalongkorn University
  More Information

No publications provided

Responsible Party: Pravit Asawanonda, Chulalongkorn University
ClinicalTrials.gov Identifier: NCT01016080     History of Changes
Other Study ID Numbers: COA840/2008
Study First Received: November 17, 2009
Last Updated: November 17, 2009
Health Authority: Thailand: Ethical Committee

Keywords provided by Chulalongkorn University:
glutathione
melanin
whitening
UV spots
skin pigment

ClinicalTrials.gov processed this record on July 23, 2014