Trial record 7 of 234 for:    Schizophrenia [CONDITION] AND NIH [SPONSOR-COLLABORATORS-CLASS] NOT NIMH [ORGANIZATION-NAME]

Internal Monitoring of Eye Movement in Schizophrenia

This study is not yet open for participant recruitment.
Verified August 2013 by National Institutes of Health Clinical Center (CC)
Sponsor:
Information provided by:
National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:
NCT01011101
First received: November 10, 2009
Last updated: March 14, 2014
Last verified: August 2013
  Purpose

Background:

  • Researchers are studying how humans are able to move our eyes to a remembered region even when the target has disappeared. The ability to do this suggests that the brain can keep track of where the eyes have looked, without an external target for continued reference. This is called corollary discharge.
  • Other research has indicated that patients with schizophrenia might have difficulty monitoring their eye movements. The corollary discharge process may be defective in patients with schizophrenia, and perhaps delayed in time. Researchers have developed a test to examine this possibility in the hope of learning more about schizophrenia and eye movement.

Objectives:

- To assess whether there is a defect in internal monitoring of eye movements in patients with schizophrenia.

Eligibility:

  • Individuals over 18 years of age who are able to give informed consent and are able to concentrate on a 20-minute task that involves following projected targets and moving their eyes to remembered locations.
  • Individuals with schizophrenia will be recruited from an ongoing NIH protocol studying schizophrenia.
  • In addition healthy will be recruited for this protocol.

Design:

  • Researchers will check participants' vision in each eye, and ask them to sit at a machine that measures eye movement in order to complete research tasks. Researchers will monitor participants ability to complete these tasks.
  • The first task involves simply following a target that jumps to different parts of the screen.
  • The second is a 2-step task, in which a participant is asked to look at two separate light targets and then look at the remembered target positions when the lights are off.
  • This protocol does not provide treatment. Participants will remain under the care of their own physicians during participation in this protocol.

Condition
Schizophrenia

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Internal Monitoring of Eye Movement in Schizophrenia

Resource links provided by NLM:


Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment: 25
Study Start Date: November 2009
Detailed Description:

OBJECTIVE:

To study if there is a defect in internal monitoring of eye movements in patients with schizophrenia.

STUDY POPULATION:

Patients with schizophrenia and normal controls.

DESIGN:

Patients and controls will be asked to follow targets to remembered locations and their eye movements will be monitored.

OUTCOME MEASURES:

Eye movements will be examined for evidence of internal monitoring (corollary discharge) defects which would result in mislocalizing remembered targets.

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria
  • INCLUSION CRITERIA:

    1. Adult subjects over 18 years of age who are able to give informed consent and are able to concentrate on a task for 20 minutes which involves following projected targets and moving their eyes to remembered locations.

EXCLUSION CRITERIA:< TAB>

  1. Large refractive error requiring strong glasses. Glasses may interfere with the video eye movement recording system. However, participants may wear contact lenses. Subjects with a history of eye disease affecting vision or eye movements will also be excluded.
  2. Participants with guardians will be excluded.
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01011101

Contacts
Contact: Edmond J FitzGibbon, M.D. (301) 496-7144 ejf@mail.nih.gov

Locations
United States, Maryland
National Institutes of Health Clinical Center, 9000 Rockville Pike Not yet recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL)    800-411-1222 ext TTY8664111010    prpl@mail.cc.nih.gov   
Sponsors and Collaborators
Investigators
Principal Investigator: Edmond J FitzGibbon, M.D. National Eye Institute (NEI)
  More Information

Additional Information:
Publications:
ClinicalTrials.gov Identifier: NCT01011101     History of Changes
Other Study ID Numbers: 100016, 10-EI-0016
Study First Received: November 10, 2009
Last Updated: March 14, 2014
Health Authority: United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):
Saccadic Eye Movements
Schizophrenia
Healthy Volunteer
HV

Additional relevant MeSH terms:
Schizophrenia
Schizophrenia and Disorders with Psychotic Features
Mental Disorders

ClinicalTrials.gov processed this record on April 23, 2014