Biomarkers for Bipolar Disorder: Chaperones and Reticulum Endoplasmatic Stress Response CHAP´s Study (CHAPS)

This study has suspended participant recruitment.
(fail to get funding)
Sponsor:
Information provided by:
University of Sao Paulo
ClinicalTrials.gov Identifier:
NCT00994630
First received: October 13, 2009
Last updated: August 15, 2011
Last verified: May 2011
  Purpose

The purpose of this study is to determine expression of chaperones proteins from the endoplasmatic reticulum stress response system in bipolar I patients (manic phase) compared to healthy controls.

Hypothesis: There is no difference in chaperones proteins expression between bipolar I manic patients and healthy controls


Condition
Bipolar Disease Type I

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: Biomarkers for Bipolar Disorder: Chaperones and Reticulum Endoplasmatic Stress Response CHAP´s Study

Resource links provided by NLM:


Further study details as provided by University of Sao Paulo:

Biospecimen Retention:   Samples With DNA

Dna and Rna analysis


Estimated Enrollment: 20
Study Start Date: January 2010
Estimated Primary Completion Date: August 2011 (Final data collection date for primary outcome measure)
Groups/Cohorts
BP I patients manic phase

  Eligibility

Ages Eligible for Study:   18 Years to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

Bipolar Disease type I manic phase

Criteria

Inclusion Criteria:

  • Bipolar Disease type I manic phase
  • YMRS > 14
  • HDRS < 9

Exclusion Criteria:

  • Use of lithium, divalproate, or carbamazepine in therapeutic levels over the past 30 days
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00994630

Locations
Brazil
Mood Disorders Program, Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo
Sao paulo, Brazil
Sponsors and Collaborators
University of Sao Paulo
Investigators
Principal Investigator: Ricardo A Moreno, MD, PhD Mood Disorders Program, Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
Study Director: Marcio G Soeiro de Souza, MD Mood Disorders Program, Institute of Psychiatry, Faculty of Medicine, University of Sao Paulo, Brazil
  More Information

No publications provided

Responsible Party: Ricardo Alberto Moreno, University of Sao Paulo
ClinicalTrials.gov Identifier: NCT00994630     History of Changes
Other Study ID Numbers: CHAPS STUDY
Study First Received: October 13, 2009
Last Updated: August 15, 2011
Health Authority: Brazil: National Committee of Ethics in Research

Additional relevant MeSH terms:
Bipolar Disorder
Affective Disorders, Psychotic
Mood Disorders
Mental Disorders

ClinicalTrials.gov processed this record on April 22, 2014