Study of Cytokines Serum Levels in Chronic Low Back Pain (cytokine)
The purpose of this study is to:
- evaluate if there is an association between elevated levels of cytokines and chronic pain due to herniated disk disease
- measured cytokines levels in chronic low back pain and in healthy subjects.
|Study Design:||Endpoint Classification: Pharmacodynamics Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Health Services Research
|Official Title:||Analytical Transversal Study of Cytokines Serum Levels in Chronic Low Back Pain Due to Herniated Disk|
- cytokines levels in patients with chronic low back pain and in healthy subjects [ Time Frame: 30 days after collect ] [ Designated as safety issue: No ]
|Study Start Date:||August 2003|
|Study Completion Date:||March 2005|
|Primary Completion Date:||September 2004 (Final data collection date for primary outcome measure)|
Serum levels of pro-inflammatory cytokines were measured using the Enzyme Linked Immuno Sorbent Assay (ELISA) technique in 23 patients with pain due to herniated disk disease (G1) as well as in 10 control healthy subject
Other: blood collect
Five milliliters of venous blood was drawn in the morning from subjects and immediately centrifuged.
Other Name: serum levels
23 patients with at least three months of back pain due to herniated disk disease were selected Diagnosis was confirmed by magnetic resonance imaging (MRI) or computerized tomography (CT) imaging of the spine for all patients. In addition, pain severity had to be ³ 5 points on the Numerical Rating Scale (NRS) ranging from zero (no pain) to 10 (worst imaginable pain).
The exclusion criteria were defined as one or more of the following: psychiatric disorders, systemic or inflammatory disease, history of allergy, presence of motor deficits, history of blood dyscrasia, pregnancy, active infection, tumor, use of analgesic drugs in the week before or inability to come to the hospital for evaluation.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00991042
|Universidade Federal da Bahia|
|Salvador, Bahia, Brazil|
|Principal Investigator:||Durval C Kraychet||Federal University of Bahia|