Carpal Tunnel Syndrome: Case Reports and Analysis - Ultrasound Imaging and Pathomechanics of Median Nerve Compression - Full Text View

Sponsor:	EMG Labs of Arizona Arthritis & Rheumatology Associates
Information provided by:	EMG Labs of Arizona Arthritis & Rheumatology Associates
ClinicalTrials.gov Identifier:	NCT00987571

Purpose

Carpal tunnel syndrome is caused by compression of the median nerve at the wrist. The hypothesis is that ultrasound imaging can be used to visualize nerve compression in carpal tunnel patients during hand activity, and normal subjects will not demonstrate any nerve compression.

Condition
Carpal Tunnel Syndrome

Study Type:	Observational
Study Design:	Case Control, Prospective
Official Title:	Carpal Tunnel Syndrome: Case Reports and Analysis - Ultrasound Imaging and Pathomechanics of Median Nerve Compression

Resource links provided by NLM:

Genetics Home Reference related topics: Charcot-Marie-Tooth disease hereditary neuropathy with liability to pressure palsies

MedlinePlus related topics: Carpal Tunnel Syndrome Ultrasound

U.S. FDA Resources

Further study details as provided by EMG Labs of Arizona Arthritis & Rheumatology Associates:

Primary Outcome Measures:

Median nerve compressive narrowing on ultrasound imaging in carpal tunnel syndrome patients [ Time Frame: 5 months ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

No median nerve compressive narrowing in normal subjects [ Time Frame: 5 months ] [ Designated as safety issue: No ]

Biospecimen Retention: None Retained

Biospecimen Description:

Enrollment:	4
Study Start Date:	April 2009
Study Completion Date:	September 2009
Primary Completion Date:	September 2009 (Final data collection date for primary outcome measure)

Groups/Cohorts
Carpal Tunnel patients These patients have documented carpal tunnel syndrome
Normal Subjects These individuals have no carpal tunnel syndrome

Detailed Description:

Two patients with carpal tunnel syndrome underwent nerve testing to document that they had median nerve abnormality at the wrist. They subsequently had ultrasound imaging of the wrist at rest and during a stress test using hand activity. Two control subjects had nerve testing to prove that they had no nerve abnormality at the carpal tunnel. The carpal tunnel syndrome patients demonstrated nerve compression on the ultrasound images during the stress tests and the normal subjects showed no nerve compression.

Eligibility

Ages Eligible for Study:	18 Years to 90 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Adult patients with upper extremity symptoms of pain, numbness, and tingling; Adult subjects with no upper extremity pain, numbness, or tingling

Criteria

Inclusion Criteria:

Patients must have symptoms consistent with carpal tunnel syndrome and electrodiagnostic testing that demonstrates abnormal median nerve function at the wrist, consistent with carpal tunnel syndrome.
Normal subjects must have no upper limb symptoms to support carpal tunnel syndrome and normal nerve testing.

Exclusion Criteria:

Patients excluded if nerve testing was not consistent with carpal tunnel syndrome.
Normals excluded if nerve testing demonstrated any median nerve abnormality.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00987571

Sponsors and Collaborators

EMG Labs of Arizona Arthritis & Rheumatology Associates

Investigators

Principal Investigator:

Benjamin M Sucher, DO

EMG Labs of AARA

More Information

No publications provided

Responsible Party:	EMG Labs of AARA ( Benjamin M. Sucher, D.O./Medical Director )
Study ID Numbers:	CTS-US Med N JAOA
Study First Received:	September 29, 2009
Last Updated:	September 30, 2009
ClinicalTrials.gov Identifier:	NCT00987571 History of Changes
Health Authority:	United States: Institutional Review Board

Keywords provided by EMG Labs of Arizona Arthritis & Rheumatology Associates:

carpal tunnel syndrome
median nerve
ultrasound
electrodiagnosis
Normal subjects

Additional relevant MeSH terms:

Median Neuropathy
Carpal Tunnel Syndrome
Disease
Nervous System Diseases
Wounds and Injuries
Disorders of Environmental Origin
Mononeuropathies

Nerve Compression Syndromes
Pathologic Processes
Neuromuscular Diseases
Syndrome
Peripheral Nervous System Diseases
Cumulative Trauma Disorders
Sprains and Strains

ClinicalTrials.gov processed this record on February 08, 2010