Inclusion Criteria:

• Age 18 years or older, males and females.
• Histologically or cytologically confirmed cancer metastatic to the liver or recurrent HCC.
• The Target Lesion must be determined to be amenable to percutaneous injection by the treating physician.
• The Target Lesion must have measurable disease, defined as a unidimensionally measurable lesion ≥ 1.0 cm in longest diameter by helical CT.
• The Target Lesion must be ≤ 3.8 cm in longest diameter (e.g., ≤ 30 cm3 in volume).
• Performance status of Karnofsky scale 60%-100% or ECOG performance scale 0-2.
• Life expectancy ≥ 12 weeks.
• Hematopoietic Function: WBC ≥ 2,500/mm3; ANC ≥ 1000/mm3; Hemoglobin ≥ 8 g/dL; Platelet count ≥ 50,000/mm3; Coagulation: INR ≤ 1.3.
• AST and ALT < 5 times ULN; ALP < 5 times ULN; Bilirubin ≤ 1.5 times ULN; Creatinine ≤ 1.5 times ULN and eGFR ≥ 50.
• Thyroid Function: Total T3 or free T3, total T4 or free T4 and THS within normal limits (WNL).
• Renal Function: Adequate renal function in the opinion of the Investigator with no clinically significant renal impairment or uncontrolled renal disease.
• Cardiovascular Function: Adequate cardiovascular function in the opinion of the Investigator with no clinically significant uncontrolled cardiovascular disease.
• Respiratory Function: Adequate respiratory function in the opinion of the Investigator with no clinically significant uncontrolled respiratory disease.
• Immunological Function: Adequate immune system function in the opinion of the Investigator with no known immunodeficiency disease.
• Informed Consent: Signed by the subject prior to screening.

Exclusion Criteria:

• Primary Resectable HCC
• Surgery: Subjects who have received hepatic surgery, ablation or chemoembolization within 4 weeks of PV-10 administration.
• Radiation Therapy: Hepatic radiation within 4 weeks of PV-10 administration.
• Chemotherapy: Chemotherapy within 4 weeks of PV-10 administration (6 weeks for nitrosoureas or mitomycin C).
• Investigational Agents: Investigational agents within 4 weeks (or 5 half-lives) of PV-10 administration.
• Phototoxic or Photosensitizing Agents: Concomitant agents posing a clinically significant risk of photosensitivity reaction within 5 half-lives of PV-10 administration.
• Concurrent or Intercurrent Illness: Uncontrolled diabetes; Significant concurrent or intercurrent illness, psychiatric disorders or alcohol or chemical dependence that would compromise Subject safety or compliance or interfere with interpretation of the study; Thyroid disease (subclinical or ongoing), goiter, partial thyroidectomy, previous radioiodine or surgically treated Graves' hyperthyroidism or cystic fibrosis, or taking thyroid hormone medication; Presence of clinically significant acute or unstable cardiovascular, cerebrovascular (stroke), renal, gastrointestinal, pulmonary, immunological (with the exception of the presence of hepatitis B virus (HBV), viral hepatitis, or cirrhosis), endocrine, or central nervous system disorders; Current encephalopathy or current treatment for encephalopathy; A documented variceal hemorrhage within 4 months of screening; History of human immunodeficiency virus or acquired immune deficiency syndrome; The clinical presence of ascites.
• Pregnancy: Female subjects who are pregnant, lactating or have positive serum β HCG pregnancy test taken within 7 days of PV-10 administration; Fertile subjects who are not using effective contraception.