Resistance and/or Endurance Training, What is Most Effective in Prevention of Cardiovascular Diseases?

This study has been completed.
Information provided by (Responsible Party):
Norwegian University of Science and Technology Identifier:
First received: September 28, 2009
Last updated: December 12, 2012
Last verified: December 2012

The aim of the present study was to evaluate the effects of aerobic interval training versus strength training or a combination of these regimes on factors comprising the metabolic syndrome in order to find the most effective exercise regime for patients with metabolic syndrome.

Condition Intervention
Metabolic Syndrome
Behavioral: aerobic exercise
Behavioral: strength training

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Strength Training Versus Aerobic Interval Training to Modify Risk Factors of the Metabolic Syndrome

Resource links provided by NLM:

Further study details as provided by Norwegian University of Science and Technology:

Primary Outcome Measures:
  • proinflammatory markers [ Time Frame: 12 weeks ] [ Designated as safety issue: No ]
    circulating interleukin-18 and interleukin-6

Enrollment: 31
Study Start Date: August 2006
Study Completion Date: March 2007
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: aerobic exercise Behavioral: aerobic exercise
carried out 3 times per week for 12 weeks
Experimental: strength training Behavioral: strength training
carried out 3 times per week for 12 weeks
No Intervention: control group

Detailed Description:

In the Western world, approximately 25% of young to middle-aged adults have metabolic syndrome. There seem to be a strong age-dependence in the prevalence of the metabolic syndrome, but the incidence rises rapidly within adolescents and middle-aged groups and follows the development of obesity in the general population. Metabolic syndrome confers an increased risk of coronary heart disease, cardiovascular disease, and premature death; therefore, effective and affordable strategies to combat the syndrome would be of great individual and social importance.

Despite the general agreement that moderate-intensity physical activity for a minimum of 30 min five days per week or vigorous-intensity aerobic physical activity for a minimum of 20 min three days a week promote and maintain health, the optimal training regime to treat metabolic syndrome and its associated cardiovascular abnormalities remains uncertain.


Ages Eligible for Study:   20 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Having metabolic syndrome according to international diabetes foundations definition (IDF).

Exclusion Criteria:

  • Unstable angina pectoris
  • Uncompensated heart failure
  • Myocardial infarction during the past 4 weeks
  • Complex ventricular arrhythmias
  • Kidney failure
  Contacts and Locations
Please refer to this study by its identifier: NCT00986024

Sponsors and Collaborators
Norwegian University of Science and Technology
Study Director: Ulrik Wisløff, md prof Norwegian University of Science and Technology
  More Information

Responsible Party: Norwegian University of Science and Technology Identifier: NCT00986024     History of Changes
Other Study ID Numbers: 460150
Study First Received: September 28, 2009
Last Updated: December 12, 2012
Health Authority: Norway:National Committee for Medical and Health Research Ethics

Keywords provided by Norwegian University of Science and Technology:
Exercise therapy

Additional relevant MeSH terms:
Cardiovascular Diseases
Metabolic Syndrome X
Insulin Resistance
Glucose Metabolism Disorders
Metabolic Diseases processed this record on April 17, 2014