Lenalidomide, Dexamethasone and Cyclophosphamide in Amyloidosis (AL) - Full Text View

Sponsor:	University of Athens
Information provided by:	University of Athens
ClinicalTrials.gov Identifier:	NCT00981708

Purpose

The purpose of this study is to determine the safety and activity of the combination of lenalidomide with intermediate dose dexamethasone and cyclophosphamide in patients with primary systemic (AL ) amyloidosis.

Condition	Intervention	Phase
Primary Systemic AL Amyloidosis	Drug: Lenalidomide, Dexamethasone and Cyclophosphamide	Phase I Phase II

Study Type:	Interventional
Study Design:	Treatment, Non-Randomized, Open Label, Uncontrolled, Single Group Assignment, Safety/Efficacy Study
Official Title:	A Phase I/II Trial of Lenalidomide Combined With Cyclophosphamide and Intermediate Dose Dexamethasone in Patients With Primary (AL) Systemic Amyloidosis

Resource links provided by NLM:

Genetics Home Reference related topics: transthyretin amyloidosis

MedlinePlus related topics: Amyloidosis

Drug Information available for: Dexamethasone Cyclophosphamide Dexamethasone acetate Doxiproct plus Lenalidomide CC 5013 Dexamethasone Sodium Phosphate

U.S. FDA Resources

Further study details as provided by University of Athens:

Primary Outcome Measures:

To assess the maximum tolerated dose of lenalidomide and cyclophosphamide and assess the hematologic response rate of the combination of Cyclophosphamide/Dexamethasone plus lenalidomide in patients with AL amyloidosis. [ Time Frame: At month 2 for assesment of maximum tolerated dose and monthly for hematologic response ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:

To assess the toxicity of Cyclophosphamide/Dexamethasone plus lenalidomide combination in patients with AL amyloidosis and organ response rate [ Time Frame: Monthly for toxicity and every 3-6 months for organ response ] [ Designated as safety issue: Yes ]

Estimated Enrollment:	30
Study Start Date:	February 2008
Estimated Study Completion Date:	February 2013
Estimated Primary Completion Date:	December 2010 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
Treatment: Experimental Lenalidomide, Dexamethasone and cyclophosphamide	Drug: Lenalidomide, Dexamethasone and Cyclophosphamide Lenalidomide capsules on days 1 to 21. the dose starts at 5 mg/day up to 25 mg/day. Dexamethasone tablets on days 1 to 4. Dose 20 mg per day. Cyclophosphamide tablets on days 1 to 10. The dose starts at 50 mg per day up to 100 mg per day. The cycle is to be repeated every 28 days (4 weeks)

Detailed Description:

Primary systemic amyloidosis (AL) is a plasma cell dyscrasia where amyloid fibrils are formed by monoclonal immunoglobulin light chains and deposit in various organs causing tissue damage and dysfunction. It is a rare disease with an incidence of 8 patients per million per year. Virtually all patients die of this disease with a median survival of 12-18 months and less than approximately 5% surviving 10 years. The current therapeutic approach to systemic amyloidosis is based on the observation that amyloid deposits can be reabsorbed and organ function can be restored if the concentration of the amyloidogenic precursor is reduced. The recognized standard treatment for patients with amyloidosis is alkylating agent-based chemotherapy - some selected patients can be treated with high dose melphalan with autologous stem cell transplantation. Recent studies have led to an improved understanding of the biology of plasma cells. Interactions between the bone marrow microenvironment and plasma cells have a critical growth regulating influence on myeloma cells. Thalidomide has shown significant activity in multiple myeloma patients with relapsing or refractory disease and even more in newly diagnosed patients. However, thalidomide causes somnolence, fatigue, constipation, and peripheral neuropathy and is not well tolerated in patients with AL amyloidosis. Lenalidomide is a small molecule structurally related to thalidomide with potent immunomodulatory effects. Lenalidomide has been found to be significantly active in relapsed multiple myeloma both in vitro and in Phase I, II and III clinical trials, including patients who had previously failed thalidomide. Unlike thalidomide, lenalidomide causes no significant sedation, constipation, neuropathy, or rash. Deep vein thrombosis ,especially in combination with dexamethasone, has been reported . Combination of thalidomide with with alkylating agents (such as melphalan or cyclophosphamide) have been very active in patients with myeloma and have superior activity than combinations of alkylating agents with steroids alone. However, the toxicity profile of thalidomide is problematic for this combination in patients with AL. combinations of lenalidomide with alkylating agents (Melphalan + prednisone +Lenalidomide)are feasible and very active in patients with multiple myeloma. Cyclophosphamide has a more favorable toxicity profile than melphalan when used in oral combinations with dexamethasone and thalidomide. However, given the remarkable antimyeloma activity of lenalidomide, overall improved toxicity profile of lenalidomide compared with thalidomide and a need for improved treatments for this incurable malignancy, the combinations of lenalidomide are worthy of study. Preliminary data from Mayo clinic using CC-5013 and dexamethasone demonstrates that lenalidomide is tolerable and has activity in patients with AL amyloidosis and may be useful in patients with AL amyloidosis who either are not candidates for high dose chemotherapy and peripheral blood stem cell transplantation or who have failed prior therapies. Efficacy and tolerability of oral cyclophosphamide , combined with dexamethasone and thalidomide, is well documented in patients with refractory or relapsed multiple myeloma while this combination has been used in patients with AL amyloidosis . Intermediate dose dexamethasone is tolerable and without significant toxicity in patients with AL amyloidosis . The combination of alkylating agents with thalidomide and dexamethasone has been effective in patients with AL amyloidosis . The combination of an alkylating agent with Lenalidomide and intermediate dose dexamethasone may lead to more rapid hematologic responses than either agent alone , and subsequently may lead to increased organ response rates . Therefore, in this phase I/II trial we explore the safety and efficacy of the combination of the alkylating agent cyclophosphamide to lenalidomide and intermediate dose dexamethasone in patients who are no candidates for high dose melphalan chemotherapy with autologous stem cell transplantation.

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Understand and voluntarily sign an informed consent form.
Age >=18 years at the time of signing the informed consent form.
Able to adhere to the study visit schedule and other protocol requirements.
Confirmed diagnosis of AL amyloidosis (see appendix 3)
Need for treatment in the judgment of their treating physician
Evaluable or measurable disease defined by any of the following:
- Measurable serum free light chains >= 10 mg/dL, kappa or lambda, provided kappa/lambda ratio is abnormal (measurable disease)
- Monoclonal protein in the serum >= 1 g/dL
ECOG Performance Status (PS) 0, 1, 2 or 3
Laboratory test results within these ranges:
- Absolute neutrophil count >= 1.5 x 109/L
- Platelet count >= 100 x 109/L
- Serum creatinine >= 2.5 mg/dL
- Total bilirubin >= 1.5 mg/dL
- AST (SGOT) and ALT (SGPT) > 2 x ULN or > 5 x ULN if hepatic metastases are present.
Women of childbearing potential (WCBP)† must have a negative serum or urine pregnancy test with a sensitivity of at least 50 mIU/mL 10 - 14 days prior to therapy and repeated within 24 hours of starting study drug and must begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 4 weeks before she starts taking lenalidomide. Women must also agree to ongoing pregnancy testing. Men must agree not to father a child and agree to use a condom if his partner is of child bearing potential. (See Appendix 1 Pregnancy Testing Guidelines and Acceptable Birth Control Methods.)
Disease free of prior malignancies for >= 5 years with exception of currently treated basal cell, squamous cell carcinoma of the skin, or carcinoma "in situ" of the cervix or breast
Able to take aspirin (81 or 325 mg) daily as prophylactic anticoagulation. (patients intolerant to ASA may use low molecular weight heparin).

Exclusion Criteria:

Patients with symptomatic multiple myeloma with asymptomatic biopsy confirmed AL amyloidosis (Appendix 3)
Any serious medical condition, laboratory abnormality, or psychiatric illness that would prevent the subject from signing the informed consent form.
Pregnant or breast feeding females. (Lactating females must agree not to breast feed while taking lenalidomide).
Any condition, including the presence of laboratory abnormalities, which places the subject at unacceptable risk if he/she were to participate in the study or confounds the ability to interpret data from the study.
Use of any other experimental drug or therapy within 28 days of baseline.
Known hypersensitivity to thalidomide.
The development of erythema nodosum if characterized by a desquamating rash while taking thalidomide or similar drugs.
Any prior use of lenalidomide.
Concurrent use of other anti-cancer agents or treatments.
Known positive for HIV or infectious hepatitis, type A, B or C.
> grade 2 peripheral neuropathy
Life expectancy < 3 months
Concurrent use of steroids (Patients may receive prednisone up to 20 mg/d, or equivalent corticosteroids for concurrent illness or adrenal replacement therapy

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00981708

Contacts

Contact: Meletios A Dimopoulos, MD	2103381540	mdimop@med.uoa.gr
Contact: Efstathios Kastritis, MD	2103381542	stathiskastritis@yahoo.com

Locations

Greece, Attica
Alexandra Hospital , Department of Clinical Therapeutics	Recruiting
Athens, Attica, Greece, 115 28
Contact: Meletios A Dimopoulos, MD 0030210 3381540 mdimop@med.uoa.gr
Contact: Efstathios Kastritis, MD 0030210 3381542 stathiskastritis@yahoo.com
Principal Investigator: Meletios A Dimopoulos, MD
Sub-Investigator: Efstathios Kastritis, MD
Sub-Investigator: Maria Roussou, MD

Sponsors and Collaborators

University of Athens

Investigators

Principal Investigator:

Meletios A Dimopoulos, MD

University of Athens, School of Medicine

More Information

No publications provided

Responsible Party:	University of Athens School of Medicine ( Professor Meletios A. Dimopoulos, MD )
Study ID Numbers:	RV-178
Study First Received:	September 19, 2009
Last Updated:	September 21, 2009
ClinicalTrials.gov Identifier:	NCT00981708 History of Changes
Health Authority:	Greece: National Organization of Medicines; Greece: Ethics Committee

Keywords provided by University of Athens:

Amyloidosis
lenalidomide
newly diagnosed
relapsed

Additional relevant MeSH terms:

Anti-Inflammatory Agents
Dexamethasone
Anti-Infective Agents
Immunologic Factors
Thalidomide
Molecular Mechanisms of Pharmacological Action
Antineoplastic Agents
Physiological Effects of Drugs
Hormones, Hormone Substitutes, and Hormone Antagonists
Antiemetics
Cyclophosphamide
Hormones
Anti-Bacterial Agents
Therapeutic Uses
Growth Inhibitors

Angiogenesis Modulating Agents
Alkylating Agents
Dexamethasone acetate
Metabolic Diseases
Antineoplastic Agents, Hormonal
Growth Substances
Lenalidomide
Gastrointestinal Agents
Angiogenesis Inhibitors
Immunosuppressive Agents
Glucocorticoids
Pharmacologic Actions
Amyloidosis
Autonomic Agents
Myeloablative Agonists

ClinicalTrials.gov processed this record on February 08, 2010