The Time of Positive Conversion of Interferon-γ Releasing Assay After Tuberculosis Exposure

This study has been completed.
Sponsor:
Information provided by:
Armed Forces Capital Hospital, Republic of Korea
ClinicalTrials.gov Identifier:
NCT00981071
First received: September 21, 2009
Last updated: April 7, 2010
Last verified: April 2010
  Purpose

The aim is to evaluate the time of positive conversion after exposure to smear positive pulmonary tuberculosis (TB) in a platoon of Korean military, a closed communal setting.


Condition
Tuberculosis

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: The Time of Positive Conversion of Interferon-γ Releasing Assay After Tuberculosis Exposure

Resource links provided by NLM:


Further study details as provided by Armed Forces Capital Hospital, Republic of Korea:

Enrollment: 32
Study Start Date: May 2009
Study Completion Date: April 2010
Primary Completion Date: April 2010 (Final data collection date for primary outcome measure)
Groups/Cohorts
A platoon with TB outbreak

Detailed Description:

In a platoon where TB outbreak occurred, we performed low dose chest CT (LDCT), QuantiFERON-TB gold in tube (QFT) and two-step (0, 4weeks) TST for outbreak investigation. We perform QFT at 0, 2, 4, 8 and 12 weeks after initial investigation for soldiers with negative QFT results, and soldiers with positive QFT and normal LDCT took isoniazid and rifampin for 3 months as treatment of latent TB.

  Eligibility

Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

A military unit in South Korean Army

Criteria

Inclusion Criteria:

  • All soldiers who assigned to the military platoon where a tuberculosis outbreak occurred

Exclusion Criteria:

  • Soldiers who could not complete study or refused the study protocol
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00981071

Sponsors and Collaborators
Armed Forces Capital Hospital, Republic of Korea
Investigators
Principal Investigator: Jae-Joon Yim, MD Seoul National University Hospital
  More Information

No publications provided

Responsible Party: Sei Won Lee/Division chief of pulmonology, Armed Forces Capital Hospital
ClinicalTrials.gov Identifier: NCT00981071     History of Changes
Other Study ID Numbers: QFTconversion
Study First Received: September 21, 2009
Last Updated: April 7, 2010
Health Authority: Korea: Food and Drug Administration

Keywords provided by Armed Forces Capital Hospital, Republic of Korea:
Tuberculosis
QuantiFERON
Outbreak
Conversion

Additional relevant MeSH terms:
Tuberculosis
Mycobacterium Infections
Actinomycetales Infections
Gram-Positive Bacterial Infections
Bacterial Infections
Interferons
Antineoplastic Agents
Therapeutic Uses
Pharmacologic Actions
Antiviral Agents
Anti-Infective Agents

ClinicalTrials.gov processed this record on April 17, 2014