Thyroid Function in Late Preterm Infants
Transient hypothyroxinemia (TH) is a condition characterized by low levels of serum thyroxine (T4) and normal levels of thyroid stimulating hormone (TSH). TH in premature infants has been found to be related to severity of illness. T4 levels in very low birth weight infants born prematurely has been found to be inversely correlated to severity of illness. In very low birth weight infants, TH has been associated with poor outcomes. Little is known about thyroid function in late preterm infants.
- Ill late preterm infants will have lower total T4 levels than healthy late preterm infants.
- Total T4 and possibly TSH levels will be inversely correlated with short-term outcomes.
- Late Preterm infants born by cesarean section will have lower T4 levels compared to those born by vaginal birth.
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Thyroid Function in Late Preterm Infants in Relation to Severity of Illness|
- Correlation of total T4 and TSH with gestational age, birth weight, and mode of delivery. [ Time Frame: First week of life ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Blood for total T4 and TSH testing will be done utilizing standardized filter paper used for the State of Delaware Newborn Screening Program.
|Study Start Date:||September 2009|
|Study Completion Date:||January 2011|
|Primary Completion Date:||January 2011 (Final data collection date for primary outcome measure)|
Late preterm infants admitted to the NICU
Please refer to this study by its ClinicalTrials.gov identifier: NCT00971555
|United States, Delaware|
|Newark, Delaware, United States, 19718|
|Principal Investigator:||Renee M Behme, MD||Christiana Hospital|
|Principal Investigator:||David A Paul, MD||Christiana Hospital|