Smoking Cessation Effect of Tea Filter Through Inhibition of Nicotine Receptor

This study has been completed.
Sponsor:
Collaborator:
Chinese Academy of Sciences
Information provided by:
General Hospital of Beijing PLA Military Region
ClinicalTrials.gov Identifier:
NCT00971529
First received: August 20, 2009
Last updated: September 3, 2009
Last verified: September 2009
  Purpose

Cigarette smoking is the major risk factor for a series of life threatening diseases including cancer and heart attack, which causes millions of deaths each year worldwide. Many of the harmful effects of cigarette smoking can be reversed by quitting; however, due to the addictive nature of nicotine, quitting smoking is extremely difficult. Despite the efforts, currently available methods produce only modest smoking cessation rates with relapse. Previously, tea components were shown to protect effect against cigarette smoke-induced toxicity. Here the investigator reported an unprecedented smoking cessation effect of tea. Green tea was made into cigarette filters and tested for its smoking cessation effect in a double-blind clinical study. The tea filter could effectively achieve abstinence relapse using smoking process to quite smoking and easy to be used by smoker without any side effects and psychological obstacles. This work provides a new idea and innovative method to combat tobacco epidemic. Its implementation and popularization may make a great contribution towards to reducing the smoking-related diseases, and relieving the public health burden and pollution caused by cigarette smoking.


Condition
Tobacco Cessation

Study Type: Observational
Study Design: Observational Model: Case Control
Official Title: Phase 1 Study on Smoking Cessation Effect of Tea Filter

Resource links provided by NLM:


Further study details as provided by General Hospital of Beijing PLA Military Region:

Primary Outcome Measures:
  • number of cigarettes consumed daily by every volunteer smoker [ Time Frame: 1-5 months ] [ Designated as safety issue: Yes ]

Secondary Outcome Measures:
  • exhaled carbon monoxide by the volunteers [ Time Frame: in the evening ] [ Designated as safety issue: Yes ]

Biospecimen Retention:   Samples Without DNA

CO


Enrollment: 159
Study Start Date: January 2009
Study Completion Date: July 2009
Primary Completion Date: May 2009 (Final data collection date for primary outcome measure)
Groups/Cohorts
lifestyle
70 volunteers were double-blinded, placebo-controlled and randomized into 2 groups (smoking with tea filters or regular filters).
tea filter
The investigators then recruited 59 volunteers with longer smoking history and stronger desire for quitting smoking for smoking cessation test using the tea filter.

  Show Detailed Description

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

70 volunteers were double-blinded, placebo-controlled and randomized into 2 groups (smoking with tea filters or regular filters).

The investigators then recruited 59 volunteers with longer smoking history and stronger desire for quitting smoking for smoking cessation test using the tea filter.

Criteria

Inclusion Criteria:

  • Healthy male cigarette smokers, aged 18 to 65 years

Exclusion Criteria:

  • Exclusion criteria included treatment with an investigational drug within the previous month
  • Major depression within the prior year
  • Panic disorder
  • Psychosis
  • Bipolar disorder
  • Use of nicotine replacement therapy or other drugs within the previous 3 months
  • Cardiovascular disease
  • Clinically significant medical disease
  • Drug or alcohol abuse or dependence within the past year
  • Use of tobacco products other than cigarette smoking within the previous month.
  Contacts and Locations
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Please refer to this study by its ClinicalTrials.gov identifier: NCT00971529

Locations
China
Ran Tao
Beijing, China, 100700
Sponsors and Collaborators
General Hospital of Beijing PLA Military Region
Chinese Academy of Sciences
Investigators
Study Director: Ran Tao, MD Addiction Branch, Beijing Military Reneral Hospital
  More Information

No publications provided

Responsible Party: Ran Tao/, Beijing Military Region General Hospital
ClinicalTrials.gov Identifier: NCT00971529     History of Changes
Other Study ID Numbers: zhaotaoliang123
Study First Received: August 20, 2009
Last Updated: September 3, 2009
Health Authority: China: The Department of Health, The General Logistics Department of Beijing Military Region

Keywords provided by General Hospital of Beijing PLA Military Region:
Smoking cessation
tea filter

ClinicalTrials.gov processed this record on August 27, 2014