Smoking Cessation Effect of Tea Filter Through Inhibition of Nicotine Receptor
Cigarette smoking is the major risk factor for a series of life threatening diseases including cancer and heart attack, which causes millions of deaths each year worldwide. Many of the harmful effects of cigarette smoking can be reversed by quitting; however, due to the addictive nature of nicotine, quitting smoking is extremely difficult. Despite the efforts, currently available methods produce only modest smoking cessation rates with relapse. Previously, tea components were shown to protect effect against cigarette smoke-induced toxicity. Here the investigator reported an unprecedented smoking cessation effect of tea. Green tea was made into cigarette filters and tested for its smoking cessation effect in a double-blind clinical study. The tea filter could effectively achieve abstinence relapse using smoking process to quite smoking and easy to be used by smoker without any side effects and psychological obstacles. This work provides a new idea and innovative method to combat tobacco epidemic. Its implementation and popularization may make a great contribution towards to reducing the smoking-related diseases, and relieving the public health burden and pollution caused by cigarette smoking.
|Study Design:||Observational Model: Case Control|
|Official Title:||Phase 1 Study on Smoking Cessation Effect of Tea Filter|
- number of cigarettes consumed daily by every volunteer smoker [ Time Frame: 1-5 months ] [ Designated as safety issue: Yes ]
- exhaled carbon monoxide by the volunteers [ Time Frame: in the evening ] [ Designated as safety issue: Yes ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||January 2009|
|Study Completion Date:||July 2009|
|Primary Completion Date:||May 2009 (Final data collection date for primary outcome measure)|
70 volunteers were double-blinded, placebo-controlled and randomized into 2 groups (smoking with tea filters or regular filters).
The investigators then recruited 59 volunteers with longer smoking history and stronger desire for quitting smoking for smoking cessation test using the tea filter.
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|Beijing, China, 100700|
|Study Director:||Ran Tao, MD||Addiction Branch, Beijing Military Reneral Hospital|