Ghrelin, Growth Hormone and Growth Factors at High Altitude

This study has been completed.
Sponsor:
Information provided by:
Medical University of Vienna
ClinicalTrials.gov Identifier:
NCT00966134
First received: August 24, 2009
Last updated: February 22, 2010
Last verified: August 2009
  Purpose

Regulation of ghrelin, growth hormone and growth factors at high altitude and their change during ascent to high altitude has not been studied in depth yet. The study includes 33 volunteers (12f) investigated at sea level, 4 days after ascent to 3440m and 14 days after ascent to 5400-5900m.

The investigators hypothesized that during ascent growth hormone levels would increase to compensate for the higher energy needs at high altitude.


Condition Intervention
Healthy
Growth Hormone
Other: exposure to high altitude

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Medical University of Vienna:

Primary Outcome Measures:
  • Ghrelin, growth hormone, insulin-like growth factor I (IGF-I), IGF binding protein 1 (IGFBP1), IGF binding protein 2 (IGFBP2), IGF binding protein 3 (IGFBP3), acid-labile subunit (ALS), insulin, prolactin [ Time Frame: 14 days ] [ Designated as safety issue: No ]

Study Start Date: April 2002
Study Completion Date: September 2005
Groups/Cohorts Assigned Interventions
probands Other: exposure to high altitude

  Eligibility

Ages Eligible for Study:   18 Years to 65 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population

Healthy Caucasians from an Alpinist association

Criteria

Inclusion Criteria:

  • Healthy and good physical fitness
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

No Contacts or Locations Provided
  More Information

No publications provided

Responsible Party: Prof Herwig Frisch, Pediatric Department
ClinicalTrials.gov Identifier: NCT00966134     History of Changes
Other Study ID Numbers: EK 411
Study First Received: August 24, 2009
Last Updated: February 22, 2010
Health Authority: Austria: Ethikkommission
Austria: Federal Ministry for Health Family and Youth

Keywords provided by Medical University of Vienna:
mountain medicine
ghrelin
growth hormone
hypoxia
physiology of hormonal adaptation to high altitude

ClinicalTrials.gov processed this record on July 22, 2014