Epidemiology of Acute Bacterial Uncomplicated Cystitis in General Practice (BaCyst)
Acute uncomplicated bacterial cystitis is common in general practice. Cystitis is at the second raw of antibiotic treatment indications. It has been now recommended not to perform any urine culture for more than 20 years; hence, the bacterial epidemiology of acute uncomplicated cystitis is surprisingly relatively unknown. The available bacteriological data mainly describe the epidemiology of complicated urinary tract infections or upper urinary tract infections, but the causative bacteria and the resistance rates might differ from those of uncomplicated cystitis. As an example, it is unknown to what extent Staphylococcus saprophyticus is the causative agent of uncomplicated cystitis.
Moreover, the urine dipstick test have been evaluated in laboratories. But their interpretation in current practice might not be so easy: in particular, the nitrite detection depends on the bacterial concentration. The nitrite detection, produced in enterobacteriaceae related infections might have therapeutical consequences: trométamol-fosfomycine is almost constantly active on enterobacteriaceae, but ineffective on staphylococci. Knowing the increasing prevalence of fluoroquinolone-resistant enterobacteriaceae, the use of fosfomycin in nitrite positive uncomplicated cystitis might preserve the susceptibility of fluoroquinolones during pyelonephritis.
This study will describe:
- the bacterial epidemiology of acute uncomplicated cystitis in general practice,
- the correlation in between urine dipstick and urine culture in general practice,
- the prediction of enterobacterial infection by the nitrite detection, AND
- the antibiotics prescribed by the practitioners for uncomplicated acute cystitis.
Acute Uncomplicated Bacterial Cystitis
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Epidemiology of Acute Bacterial Uncomplicated Cystitis in General Practice: Description and Prediction by Urine Dipstick Test|
- Bacterial epidemiology of acute uncomplicated cystitis [ Time Frame: march 2010 ] [ Designated as safety issue: No ]
- Comparison of urine dipstick tests and urine culture results [ Time Frame: march 2010 ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
Bacterial strains isolated in urine cultures
|Study Start Date:||March 2009|
|Study Completion Date:||June 2010|
|Primary Completion Date:||May 2010 (Final data collection date for primary outcome measure)|
|Louviers, France, 27400|
|Principal Investigator:||Manuel ETIENNE, MD||Infectious diseases department, rouen university hospital|