Body Composition Assessment in Spinal Cord Injury
Recruitment status was Recruiting
The purpose of this research is to evaluate different methods of measuring body composition (amount of fat, muscle, bone, and water in your body) and to determine relationships between body composition and other medical problems associated with spinal cord injury (SCI).
Spinal Cord Injury
Other: Body composition
|Study Design:||Time Perspective: Prospective|
|Official Title:||Body Composition Assessment in Spinal Cord Injury|
- To compare different methods of body composition analyses with the gold standard 4-compartment monitoring to determine accuracy and validity of those alternative, but less labor-intensive techniques. [ Time Frame: 3 years ] [ Designated as safety issue: No ]
- To assess the relationship between % body fat, visceral fat, and markers of the metabolic syndrome, including Plasminogen Activator Inhibitor-1 (PAI-1), Thrombin-Activatable Fibrinolysis Inhibitor (TAFI), and high-sensitivity C-Reactive Protein (hsCRP) [ Time Frame: 3 years ] [ Designated as safety issue: No ]
- To develop body composition regression equations that can be easily utilized in a clinical setting to estimate risk for the metabolic syndrome in persons with SCI. [ Time Frame: 3 years ] [ Designated as safety issue: No ]
- To cross-validate the derived regression equations against the gold standard 4-compartment model in an independent group of persons with SCI. [ Time Frame: 3 years ] [ Designated as safety issue: No ]
|Study Start Date:||August 2009|
|Estimated Study Completion Date:||October 2012|
|Estimated Primary Completion Date:||September 2012 (Final data collection date for primary outcome measure)|
120 subjects will help create the regression models. The remaining 50 subjects will be recruited to determine if the equations work for the population.
Other: Body composition
Day 1 testing will incorporate underwater weighing, Bod Pod, DXA, BIA and anthropometrics. Day 2 will include RMR, MRI, and testing at GCRC
A preliminary investigation in our laboratory has demonstrated the advantage of using 4-compartment modeling to assess body composition in SCI adults. In comparing body composition analyses techniques in 20 individuals with SCI, we found Total Error to be 8.0% with Dual X-ray Absorptiometry, 8.4% with hydrodensitometry, 11.5% with bioelectrical impedance analysis, and 21.8% with standard skinfold equations when compared to 4-compartment modeling, the currently accepted gold standard for body composition assessment. To date there is no gold standard for the determination of body composition in SCI individuals.
|Contact: Joshua Miller, MS||804-675-6200||Joshua.Miller@va.gov|
|United States, Virginia|
|Hunter Holmes McGuire Spinal Cord Injury Research Lab||Recruiting|
|Richmond, Virginia, United States, 23249|
|Contact: Joshua Miller, MS 804-675-6200 Joshua.Miller@va.gov|
|Principal Investigator:||David R Gater, MD, PhD||Hunter Holmes McGuire VAMC|