Use of Human Papillomavirus Persistence for Determination of Treatment Efficacy Among Women With Cervical Dysplasia
The objectives are to evaluate the effectiveness of treatment of cervical intraepithelial neoplasia (CIN) by loop electrosurgical excision procedure using persistence of human papillomavirus (HPV) as outcome, and to perform a long-term follow-up on the ability of HPV testing, as compared to cytology, to predict recurrence of high-grade CIN.
Human Papillomavirus Infection
Cervical Intraepithelial Neoplasia
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Evaluation of the Use of Human Papillomavirus Persistence for Determination of the Treatment Efficacy Among Women With Cervical Intraepithelial Neoplasia, and for Prediction of Recurrence of Cervical Disease|
Cervical smear samples in physiologic saline.
|Study Start Date:||February 2001|
|Study Completion Date:||November 2005|
Cervical samples for human papillomavirus (HPV) DNA analysis and cytological analysis were obtained from women with abnormal smears referred to Umeå university hospital, Sweden, for treatment with conization. These women were scheduled for HPV DNA testing and Pap smears before and 3, 6, 12, 24 and 36 months after treatment. The HPV DNA testing was performed with a PCR-based genotyping method.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00931190
|Dept. obstetrics and gynecology, University hospital of Northern Sweden|
|Umeå, Sweden, 90185|
|Principal Investigator:||Anna Söderlund Strand, PhD||Dept. medical microbiology, Malmö university hospital, Malmö, Sweden|