Mechanisms of Neural Mobilization in the Treatment of Chronic Pain

This study has been completed.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
University of Florida
ClinicalTrials.gov Identifier:
NCT00929123
First received: June 25, 2009
Last updated: December 21, 2011
Last verified: June 2010
  Purpose

The purpose of this study was to determine the effect of a manual therapy technique (neural mobilization) on measures of clinical pain and function, experimental pain sensitivity, and on the function of the median nerve in individuals with carpal tunnel syndrome. The investigators hypothesized that individuals receiving a neural mobilization technique known to directly stress the median nerve would demonstrate greater improvements in clinical pain and function, experimental pain sensitivity, and median nerve function than those receiving a sham technique.


Condition Intervention Phase
Carpal Tunnel Syndrome
Procedure: neural mobilization
Procedure: sham neural mobilization
Other: healthy controls
Phase 1
Phase 2

Study Type: Interventional
Study Design: Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Mechanisms of Neural Mobilization in the Treatment of Chronic Pain

Resource links provided by NLM:


Further study details as provided by University of Florida:

Primary Outcome Measures:
  • thermal and pressure pain sensitivity [ Time Frame: immediate effect ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • grip strength [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
  • wrist range of motion [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
  • clinical pain [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
  • self report of disability [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]
  • median nerve function [ Time Frame: 3 weeks ] [ Designated as safety issue: No ]

Enrollment: 40
Study Start Date: May 2007
Study Completion Date: June 2009
Primary Completion Date: July 2008 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: neural mobilization
manual therapy technique known to directly stress the median nerve
Procedure: neural mobilization
manual therapy technique known to directly stress the median nerve
Other Name: upper limb tension test with median nerve bias
Placebo Comparator: sham neural mobilization Procedure: sham neural mobilization
sham technique mimicking the neural mobilization which is not specific to the median nerve
No Intervention: Healthy Controls
People without carpal tunnel syndrome for comparison
Other: healthy controls
People without carpal tunnel syndrome for comparison

  Eligibility

Ages Eligible for Study:   18 Years to 70 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • 18 to 70 years of age
  • signs and symptoms of carpal tunnel syndrome for greater than 12 weeks

Exclusion Criteria:

  • non english speaking
  • prior surgery for carpal tunnel syndrome
  • systemic condition known to affect sensation
  • chronic pain condition other than carpal tunnel syndrome
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00929123

Locations
United States, Florida
University of Florida
Gainesville, Florida, United States, 32611
Sponsors and Collaborators
University of Florida
Investigators
Principal Investigator: Steven Z George, PhD University of Florida Department of Physical Therapy
  More Information

Publications:
Responsible Party: University of Florida
ClinicalTrials.gov Identifier: NCT00929123     History of Changes
Other Study ID Numbers: R21 AT002796, R21AT002796, R21 AT002796-01A1
Study First Received: June 25, 2009
Last Updated: December 21, 2011
Health Authority: United States: Federal Government

Keywords provided by University of Florida:
manual therapy
carpal tunnel syndrome
central sensitization

Additional relevant MeSH terms:
Carpal Tunnel Syndrome
Chronic Pain
Syndrome
Cumulative Trauma Disorders
Disease
Median Neuropathy
Mononeuropathies
Nerve Compression Syndromes
Nervous System Diseases
Neurologic Manifestations
Neuromuscular Diseases
Pain
Pathologic Processes
Peripheral Nervous System Diseases
Signs and Symptoms
Sprains and Strains
Wounds and Injuries

ClinicalTrials.gov processed this record on October 30, 2014