Investigations Regarding B-cell Subsets in Humans
The aim of this research is to define the human equivalent of mouse B1 cells.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Investigations Regarding B-cell Subsets in Humans|
- Presence of B-1 cells in humans [ Time Frame: determined over the years study in effect ] [ Designated as safety issue: No ]an equivalent cell type was isolated in humans
|Study Start Date:||April 2009|
|Estimated Study Completion Date:||July 2014|
|Estimated Primary Completion Date:||July 2014 (Final data collection date for primary outcome measure)|
All subjects are considered healthy
Other: Blood draw
Subject will have blood draw.
The specific aim of this research project is to define the human equivalent of mouse B1 cells. This will be done by evaluating IgM secretion, surface markers, functional characteristics, V gene usage, N-region addition, and phosphorylation status of intracellular proteins, gene expression, sequencing of immunoglobulin genes, determination of antigenic specificity, replication history, and response to different stimuli.
The goal of this project is to begin to the translation of decades of basic science research and research in the mouse model into the human system. It is believed that properly defining this B cell subset in humans will lead to better therapeutics, prognostics and prevention for a number of disease including infections, autoimmune disease, and cancer.
|United States, New York|
|Feinstein Institute for Medical Research|
|Manhasset, New York, United States, 11030|
|Principal Investigator:||Daniel Griffin, M.D.||Feinstein Institute for Medical Research|