Brain-derived Neurotrophic Factor Participates in Visceral Hyperalgesia in Irritable Bowel Syndrome (IBS) Patients
Brain-derived neurotrophic factor (BDNF), originally known to be a member of the nerve growth factor family, has aroused attention as a modulator in visceral hyperalgesia recently. Visceral hypersensitivity is recognized as a clinical hallmark in IBS patients. So in this study, the investigators will focus on the role of BDNF in colonic hyperalgesia in IBS patients.
Irritable Bowel Syndrome
|Study Design:||Observational Model: Case Control|
|Official Title:||Study of Brain-derived Neurotrophic Factor in Visceral Hyperalgesia in IBS Patients|
two mucosal biospecimens will be obtained from the rectosigmoid junction from each patient.
|Study Start Date:||June 2009|
|Estimated Study Completion Date:||November 2009|
|Estimated Primary Completion Date:||August 2009 (Final data collection date for primary outcome measure)|
irritable bowel syndrome
patients with diarrhea-predominant IBS will be enrolled in this group.
patients with colon cancer or colon polyp will be enrolled as control group.