Efficacy of Sterol Enhanced Soy Beverage on Cholesterol Metabolism, Inflammation and Oxidative Status in Humans
It is becoming increasingly clear that North Americans prefer dietary approaches to enhance health in favour of pharmaceutical approaches. Although the consumption of various phytosterol (PS)-enriched foods have been shown to be effective in lowering plasma cholesterol in a variety of food matrices, the lipid-lowering potential of PS-enriched soymilk has not been investigated. Therefore, the objective of this investigation was to examine the lipid-lowering efficacy of a PS-enriched soymilk beverage in comparison to a 1% dairy milk control. Twenty-three hypercholesterolemic subjects (Total-cholesterol and LDL-cholesterol ≥ 5.0 and 3.5 mmol/L, respectively) consumed 3 tetrapacs per day of a phytosterol-enriched soy beverage providing 1.95g PS/d or a 1% dairy milk control. The study was conducted as a 28 d controlled dietary intervention according to a completely randomized, two-period cross-over design.
Coronary Heart Disease
Dietary Supplement: phytosterol enhanced soy based beverage
Dietary Supplement: 1% milk
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Crossover Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Efficacy of Sterol Enhanced Soy Beverage on Cholesterol Metabolism, Inflammation and Oxidative Status in Humans Study 1|
- cholesterol [ Time Frame: 30 days ] [ Designated as safety issue: No ]
|Study Start Date:||September 2007|
|Study Completion Date:||August 2008|
|Primary Completion Date:||December 2007 (Final data collection date for primary outcome measure)|
Active Comparator: dairy milk
Control phase with 1% milk.
|Dietary Supplement: 1% milk|
Experimental: phytosterol enhanced soy based beverage
Treatment phase where control-phase diets are provided with phytosterol enhanced soy based beverage.
|Dietary Supplement: phytosterol enhanced soy based beverage|
|Richardson Centre for Functional Foods and Nutraceuticals|
|Winnipeg, Manitoba, Canada, R3T 2N2|
|Principal Investigator:||Peter JH Jones, B.ScM.ScPh.D||Richardson Centre for Functional Foods and Nutraceuticals|