Collecting and Storing Blood and Brain Tumor Tissue Samples From Children With Brain Tumors

This study is currently recruiting participants. (see Contacts and Locations)
Verified November 2012 by National Cancer Institute (NCI)
Information provided by:
National Cancer Institute (NCI) Identifier:
First received: June 11, 2009
Last updated: November 9, 2012
Last verified: November 2012

RATIONALE: Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.

PURPOSE: The purpose of this study is to collect and store brain tissue samples and blood from children with brain cancer that will be tested in the laboratory.

Condition Intervention
Brain and Central Nervous System Tumors
Other: biologic sample preservation procedure

Study Type: Observational
Official Title: A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens

Resource links provided by NLM:

Further study details as provided by National Cancer Institute (NCI):

Primary Outcome Measures:
  • Collection of brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children's Oncology Group institutions [ Designated as safety issue: No ]
  • Creation of a repository for long-term storage of these specimens [ Designated as safety issue: No ]
  • Making these specimens available to qualified researchers to understand the biology of pediatric brain tumors [ Designated as safety issue: No ]

Study Start Date: March 2005
Detailed Description:


  • Collect brain tumor tissue and an accompanying blood sample from pediatric patients with brain tumors treated at Children's Oncology Group institutions.
  • Provide a repository for long-term storage of specimens from these patients.
  • Make these specimens available to qualified researchers to understand the biology of pediatric brain tumors.

OUTLINE: This is a multicenter study

Brain tumor tissue and blood specimens are collected from patients and banked for future study.

PROJECTED ACCRUAL: An unlimited number of specimens will be collected.


Ages Eligible for Study:   up to 18 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No


  • Diagnosis of brain tumor
  • Previously treated at a Children's Oncology Group (COG) institution

    • Patients are eligible at time of diagnosis, second-look surgery, recurrence, or development of a second malignant neoplasm
  • Must have brain tumor biological specimens derived from primary tumors of the CNS available for submission


  • Not specified


  • Not specified
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00919750

  Show 160 Study Locations
Sponsors and Collaborators
Children's Oncology Group
Study Chair: Scott Pomeroy, MD Children's Hospital Boston
Investigator: Jaclyn A. Biegel, PhD Children's Hospital of Philadelphia
  More Information

Additional Information:
No publications provided Identifier: NCT00919750     History of Changes
Obsolete Identifiers: NCT00228748
Other Study ID Numbers: CDR0000352347, COG-ACNS02B3
Study First Received: June 11, 2009
Last Updated: November 9, 2012
Health Authority: Unspecified

Keywords provided by National Cancer Institute (NCI):
childhood grade I meningioma
childhood grade II meningioma
childhood grade III meningioma
recurrent childhood cerebellar astrocytoma
recurrent childhood cerebral astrocytoma
recurrent childhood ependymoma
recurrent childhood medulloblastoma
recurrent childhood supratentorial primitive neuroectodermal tumor
recurrent childhood visual pathway and hypothalamic glioma
recurrent childhood visual pathway glioma
childhood central nervous system germ cell tumor
newly diagnosed childhood ependymoma
childhood choroid plexus tumor
childhood craniopharyngioma
childhood infratentorial ependymoma
childhood oligodendroglioma
childhood supratentorial ependymoma
childhood high-grade cerebral astrocytoma
childhood low-grade cerebral astrocytoma
childhood atypical teratoid/rhabdoid tumor

Additional relevant MeSH terms:
Brain Neoplasms
Nervous System Neoplasms
Central Nervous System Neoplasms
Neoplasms by Site
Brain Diseases
Central Nervous System Diseases
Nervous System Diseases processed this record on July 28, 2014