Investigation of the Effects of Exercise on Gene Expression

This study has been completed.
Information provided by:
Fukuoka University Identifier:
First received: June 4, 2009
Last updated: June 15, 2009
Last verified: June 2009

The investigators have previously shown that mild exercise training at the level of lactate threshold (LT) intensity (60 min/day, 5 days/week) improves peripheral insulin sensitivity and insulin-independent glucose disposal of glucose effectiveness, without changes in body weight and body fat (Nishida et al, Diabetes Care, 2001; Nishida et al, Diabetes, 2004). Thus these beneficial effects are likely related to a number of adaptations that occur in skeletal muscle as response to exercise. In the current study, the investigators hypothesised that a single bout of mild exercise performed at LT would be a physiological stimulator of skeletal muscle PGC-1alpha gene, and the repetition of this exercise stimulating PGC-1alpha gene (i.e., training) for 12 weeks would induce coordinated increases in a large number of metabolic genes, as well as other genes potentially important in the prevention of insulin resistance and metabolic syndrome.

Condition Intervention
Other: exercise training

Study Type: Interventional
Study Design: Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Basic Science
Official Title: Investigation on Gene Expression and Gene Marker Accompanied by a Single Bout of Exercise and Exercise Training

Resource links provided by NLM:

Further study details as provided by Fukuoka University:

Primary Outcome Measures:
  • Skeletal muscle PGC-1alpha gene expression and mitochondrial gene expression [ Time Frame: 3 months ] [ Designated as safety issue: No ]

Enrollment: 6
Study Start Date: July 2002
Study Completion Date: December 2007
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: exercise
mild exercise training
Other: exercise training
60 min of low-intensity exercise, 5 days/week, 12 weeks


Ages Eligible for Study:   19 Years to 32 Years
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Men who were all in good health
  • All individuals were free from diabetes and none were taking any medications
  • All subjects were asked not to change their normal dietary habits, and not to engage in any strenuous physical activity

Exclusion Criteria:

  • People who undergone regular exercise for at least 2 years
  • Smokers
  Contacts and Locations
Please refer to this study by its identifier: NCT00916019

Fukuoka University
Fukuoka, Japan, 814-0133
Sponsors and Collaborators
Fukuoka University
Principal Investigator: Hiroaki Tanaka, Ph.D. Fukuoka University
  More Information

No publications provided

Responsible Party: Hiroaki Tanaka, Ph.D, Fukuoka University Identifier: NCT00916019     History of Changes
Other Study ID Numbers: 19200049
Study First Received: June 4, 2009
Last Updated: June 15, 2009
Health Authority: Japan: Ministry of Education, Culture, Sports, Science and Technology

Keywords provided by Fukuoka University:
gene expression
skeletal muscle
Healthy men processed this record on April 17, 2014