Visual Exploration and Attention: Studies in Patients With Schizophrenia and Autism Spectrum Disorders
This study is currently recruiting participants.
Verified June 2012 by University Hospital, Strasbourg, France
Sponsor:
University Hospital, Strasbourg, France
Information provided by (Responsible Party):
University Hospital, Strasbourg, France
ClinicalTrials.gov Identifier:
NCT00914030
First received: June 2, 2009
Last updated: June 28, 2012
Last verified: June 2012
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Purpose
The aim of the protocol is to better understand the impairments in visual processing, as such impairments may induce social interaction difficulties in subjects with autism spectrum disorders (adults and children) and schizophrenia, like face exploration.The same protocol will be used for the three populations, each population being compared with matched controls. The explorations are designed to test two different hypotheses regarding the mechanisms of the visual perception difficulties of the two populations. Even though difficulties to extract the global form of objects have been described in both subjects with autism and schizophrenia, we will test two different hypotheses for the two populations. We will test the hypothesis that subjects with autism display an advantage for the processing of local information arising at an early level of processing, whereas disorders observed in patients with schizophrenia originate from attention disorders. The protocol includes three consecutive studies, each one being applied in each of the three populations.
| Condition | Intervention |
|---|---|
|
Autism Spectrum Disorders Schizophrenia |
Other: Neuropsychological evaluation |
| Study Type: | Observational |
| Study Design: | Observational Model: Case Control Time Perspective: Cross-Sectional |
| Official Title: | Visual Exploration and Attention : Studies in Patients With Schizophrenia and Autism Spectrum Disorders |
Resource links provided by NLM:
Further study details as provided by University Hospital, Strasbourg, France:
| Estimated Enrollment: | 140 |
| Study Start Date: | June 2009 |
| Estimated Study Completion Date: | August 2014 |
| Estimated Primary Completion Date: | July 2014 (Final data collection date for primary outcome measure) |
| Groups/Cohorts | Assigned Interventions |
|---|---|
|
A1
Patients with schizophrenia
|
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
|
|
A2
Control subjects matched individually with patients with schizophrenia
|
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
|
|
B1
Adult subjects with autism
|
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
|
|
B2
Control subjects matched individually with adult subjects with autism
|
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
|
|
C1
Children with autism
|
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
|
|
C2
Control subjects matched individually with children with autism
|
Other: Neuropsychological evaluation
Study one: global/local processing, with a neutral prime (stimulus influencing the processing of the subsequent stimulus)Study two: global/ local processing with a prime whose elements are collinear.Study three: global/local processing with a prime whose elements are not collinear
Other Name: Each study will be conducted successively in each group (A1/ A2, B1/B2, C1/C2).
|
Eligibility| Ages Eligible for Study: | 7 Years to 55 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | Yes |
| Sampling Method: | Non-Probability Sample |
Study Population
Psychiatry clinic in Strasbourg and Brumath. Pedopsychiatry Clinic in Strasbourg. Residents of Strasbourg and Brumath
Criteria
Inclusion Criteria:
- IQ above 70, as evaluated with the WAIS III in adults and with the WISC in children
- signed consent
- DSM IV criteria in case of autism spectrum disorders or schizophrenia
Exclusion Criteria:
- grave or non stabilized somatic pathology
- pathology affecting the central nervous system; other than the studied pathologies
- intake of psychotropic drug, except for patients
- invalidating sensory processes
Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00914030
Contacts
| Contact: GIERSCH Anne, MD | giersch@unistra.fr |
Locations
| France | |
| Pôle départemental du Centre de Ressources Autisme pour adultes (67) - Etablissement public de santé Alsace-Nord (site de Brumath) | Recruiting |
| Brumath, France, 67170 | |
| Contact: HOCHNER Arielle, MD arielle.hochner@ch-epsan.fr | |
| Principal Investigator: HOCHNER Arielle, MD | |
| Sub-Investigator: WEINER Luisa, MD | |
| Centre de Ressources Autisme Pôle adultes (68) - Espace Autisme 68 | Recruiting |
| Colmar, France, 68000 | |
| Contact: MURAD Ayman, MD murad@ch-rouffach.fr | |
| Principal Investigator: MURAD Ayman, MD | |
| Clinique Lautréamont | Recruiting |
| Loos, France, 59120 | |
| Contact: GONIN Olivier, MD Olivier.gonin4@wanadoo.fr | |
| Principal Investigator: GONIN Olivier, MD | |
| INSERM U666 ; Pôle de Psychiatrie - Service de Psychiatrie Adulte- HUS | Recruiting |
| Strasbourg, France, 67091 | |
| Contact: GIERSCH Anne, MD giersch@unistra.fr | |
| Principal Investigator: GIERSCH Anne, MD | |
| Pôle régional du Centre de Ressources Autisme pour enfants et adolescents - Unité d'évaluation des troubles du développement Hôpital de l'Elsau - Pôle de Psychiatrie - Unité d'évaluation des troubles du développement Hôpital de l'Elsau - HUS | Recruiting |
| Strasbourg, France, 67000 | |
| Contact: GRAS-VINCENDON Agnès, MD agnes.gras@chru-strasbourg.fr | |
| Principal Investigator: GRAS-VINCENDON Agnès, MD | |
| Sub-Investigator: CHABAUX-DELARAI Catherine, MD | |
Sponsors and Collaborators
University Hospital, Strasbourg, France
Investigators
| Principal Investigator: | Anne GIERSCH | Institut National de la Santé Et de la Recherche Médicale, France |
More Information
No publications provided
| Responsible Party: | University Hospital, Strasbourg, France |
| ClinicalTrials.gov Identifier: | NCT00914030 History of Changes |
| Other Study ID Numbers: | 4371 (2008-A01459-46) |
| Study First Received: | June 2, 2009 |
| Last Updated: | June 28, 2012 |
| Health Authority: | France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis) |
Keywords provided by University Hospital, Strasbourg, France:
|
Visual perception Local/global processing Attention |
Visual priming Collinearity Grouping |
Additional relevant MeSH terms:
|
Autistic Disorder Schizophrenia Child Development Disorders, Pervasive |
Mental Disorders Diagnosed in Childhood Mental Disorders Schizophrenia and Disorders with Psychotic Features |
ClinicalTrials.gov processed this record on May 21, 2013