Analyzing Composition and Lubrication Properties of Synovial Fluid (SFCL)

This study has been completed.
Sponsor:
Collaborator:
National Science Concil
Information provided by:
Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier:
NCT00912106
First received: June 2, 2009
Last updated: NA
Last verified: June 2009
History: No changes posted
  Purpose

To analyze the relationship between composition of synovial fluid and its lubrication properties


Condition Intervention
Knee Osteoarthritis
HA Injection
One Injection Per Week for Five Week
Synovial Fluid Composition
Synovial Fluid Lubrication
Other: Synovial fluid composition and lubrication analysis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Boundary Lubrication of Synovial Fluid Molecules and Its Effect on the Surrounding Cells and Tissues

Resource links provided by NLM:


Further study details as provided by Far Eastern Memorial Hospital:

Primary Outcome Measures:
  • Synovial fluid HA and albumin concentration; synovial fluid lubrication [ Time Frame: 1 wk, 2 wk, 3 wk, 4 wk, 5 wk ] [ Designated as safety issue: Yes ]

Biospecimen Retention:   Samples Without DNA

synovial fluid from knee joint


Enrollment: 55
Study Start Date: April 2008
Study Completion Date: June 2009
Primary Completion Date: December 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts Assigned Interventions
HA injection
Patients with osteoarthritis of knee. They are going to received HA injection 1 vial per week for 5 weeks.
Other: Synovial fluid composition and lubrication analysis
Before HA injection, synovial fluid must be drawn to increase treatment effectiveness. The drawn synovial fluid was then analyzed in the lab. There was no influence for patients enrolled because the drawn synovial fluid would usually be discarded.

Detailed Description:

Patients suffering from serious arthritis may receive the artificial joint replacement surgery. Comparing to the articulation of articular cartilage, the artificial joint undergo a boundary lubrication in which a thin layer of synovial fluid molecules is formed between the artificial joint materials. Therefore a larger wear rate is observed in the artificial joint system. Researchers have devoted themselves to modifying the artificial joint materials in order to reduce the wear phenomena. We first propose that modification the lubrication by adding effective lubricating molecules may help to reduce the wear of artificial joint. However, there still lacks fundamentally understanding of the artificial joint lubrication mechanism under synovial fluid. Hence, we plan to investigate the boundary lubrication mechanism of synovial molecules, such as albumin, globulin, hyaluronic acid, and lipid in the first year. We would like to obtain the adsorption behaviors of the single molecules as well as multiple molecules on the surfaces of artificial joint materials by experiments. Molecular dynamics simulation will also be performed to gain the knowledge of adsorption energy and possible conformation change of the molecules. In the second year, the tribological heat and mechanical effects on the synovial molecules will be studied. The analysis platform will be established to perform the composition and properties measurement of the synovial molecules. In the third year, we will further discuss the effect of the synovial molecules transformation on the surrounding cells and tissues. Their influences on the tribological and biochemical behaviors will be investigated.

  Eligibility

Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

Patients who are going to receive HA injection of one or two knees

Criteria

Inclusion Criteria:

  • Patients who are going to receive HA injection of one or two knees

Exclusion Criteria:

  • Patients whose quantity of synovial fluid is not enough to be drawn
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00912106

Locations
Taiwan
Far Eastern Memorial Hospital
Pan-Ciao, Taipei, Taiwan, 22050
Sponsors and Collaborators
Far Eastern Memorial Hospital
National Science Concil
Investigators
Study Director: Chih-Hung Chang, Ph. D Far Eastern Memorial Hospital
  More Information

No publications provided

Responsible Party: Chih-Hung Chang, Division of Orthopedics, Far Eastern Memorial Hospital
ClinicalTrials.gov Identifier: NCT00912106     History of Changes
Other Study ID Numbers: 96024, NSC-96-
Study First Received: June 2, 2009
Last Updated: June 2, 2009
Health Authority: Taiwan: Department of Health

Keywords provided by Far Eastern Memorial Hospital:
osteoarthritis
HA
synovial fluid
lubrication

Additional relevant MeSH terms:
Osteoarthritis
Osteoarthritis, Knee
Arthritis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases

ClinicalTrials.gov processed this record on August 28, 2014