Natural Supplements and a Special Diet in Eliminating Growth Hormones Made Outside the Body in Patients With Early-Stage Prostate Cancer, Breast Cancer, or Uterine Cancer

• Sequestration and elimination of exogenous estrogens from the body using multiple naturally-occurring micro-trace element compounds [ Time Frame: 6 months ] [ Designated as safety issue: No ]
  lowering body estrogens as related to hormone driven cancer
  
  
• Suppression of proliferation-stimulating activities using naturally-occurring flavonoids [ Time Frame: 6 months ] [ Designated as safety issue: No ]
  suppress cancer cell proliferation
  
  
• Reduction of secondary bonding of TMPRSS2-ERG fusing and negative-bonded environmental estrogen using DPPH radical-scavenging activity [ Time Frame: 6 months ] [ Designated as safety issue: No ]
  Monitor levels
  
  
• Maintenance of normal metabolic function using a full diet of specifically grown inclusion produce [ Time Frame: 6 months ] [ Designated as safety issue: No ]
  metabolic function testing
  
  

OBJECTIVES:

• To utilize multiple naturally-occurring micro-trace element compounds to sequester exogenous estrogens from multiple sources, including environmental and metabolic sources, and eliminate them from the body prior to influencing prostate, breast, and uterine cancer pathways.
• To utilize specific naturally-occurring flavonoids to suppress proliferation-stimulating activities induced by normal metabolism and environmental estrogen, estrogen-mimicking, and testosterone compounds.
• To utilize DPPH radical-scavenging activity to reduce secondary bonding of TMPRSS2-ERG fusing and negative-bonded environmental estrogen.
• To utilize a full diet of specifically grown inclusion produce to maintain normal metabolic function.

OUTLINE: Patients are randomized to 1 of 2 arms.

• Arm I: Patients receive oral natural supplements comprising indole-3-carbinol, perillyl alcohol, glucuronic acid, and flavonoids daily for 12 months. Patients also consume whole foods comprising indole-3-carbinol and a diet that eliminates exogenous growth hormones.
• Arm II: Patients do not receive natural supplements or consume whole foods or a special diet.

Levels of compounds of interest are measured by inductively-coupled plasma mass spectrometry, high performance liquid chromatography, gas chromatography, and matrix-assisted laser desorption/ionization time of flight mass spectrometry.

After completion of study therapy, patients are followed periodically for 6 months.