Phenotypic and Genetic Factors in Autism Spectrum Disorders
- Full Text View
- Tabular View
- No Study Results Posted
- Disclaimer
- How to Read a Study Record
Purpose
The purpose of the study is to collect phenotypic (observable characteristics) and genetic information about individuals with Autism Spectrum Disorders (ASDs) and their families.
| Condition |
|---|
|
Autism Spectrum Disorders |
| Study Type: | Observational |
| Study Design: | Observational Model: Family-Based Time Perspective: Cross-Sectional |
| Official Title: | Phenotypic and Genetic Factors in Autism Spectrum Disorders |
Whole blood
| Estimated Enrollment: | 1500 |
| Study Start Date: | July 2008 |
| Estimated Study Completion Date: | February 2013 |
| Estimated Primary Completion Date: | February 2013 (Final data collection date for primary outcome measure) |
Participation in this research study involves two research visits, at least one of which is at Children's Hospital Boston. The first visit lasts about 4-6 hours. On this visit, the child will work with a research assistant on a few different cognitive assessments while one or both parents answer interview questionnaires about the child's development, along with other family history information. The second visit at the hospital lasts about 2 and a half hours and involves medical history and family history questionnaires, as well as height, weight, and head circumference measurements and a blood draw from each family member. In addition, digital photographs will be taken of each family member and a 3-D picture of the child's face will be taken. Shortly after the visits, participants will receive a research report of our observations. These results include cognitive, behavioral, developmental, and social findings. The total time commitment for the study is 6 to 8 hours.
Eligibility| Ages Eligible for Study: | 18 Months and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Individuals with ASDs and their parents and/or siblings
Inclusion Criteria:
- Diagnosis of autism spectrum disorder or suspected diagnosis based on clinical genetic test results (e.g., variant diagnosed via chromosomal microarray)
- Age ≥ 18 months
Exclusion Criteria:
- Presence of a metabolic disorder
- Acquired developmental disability (e.g., birth asphyxia, trauma-related injury, meningitis, etc.) or cerebral palsy
Contacts and Locations| United States, Massachusetts | |
| Children's Hospital Boston | Recruiting |
| Boston, Massachusetts, United States, 02115 | |
| Contact: Joanna Reinwald, M.S. 617-355-9152 joanna.reinwald@childrens.harvard.edu | |
| Principal Investigator: Louis Kunkel, Ph.D. | |
| Principal Investigator: | Louis Kunkel, PhD | Children's Hospital Boston |
More Information
No publications provided
| Responsible Party: | Louis Kunkel Ph.D., Children's Hospital Boston |
| ClinicalTrials.gov Identifier: | NCT00910559 History of Changes |
| Other Study ID Numbers: | 04-05-075, 1R01MH085143-01 |
| Study First Received: | May 29, 2009 |
| Last Updated: | September 13, 2011 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by Children's Hospital Boston:
|
Autism Spectrum Disorder ASD Autism |
Asperger Syndrome PDD-NOS Pervasive Developmental Disorders- Not Otherwise Specified |
Additional relevant MeSH terms:
|
Autistic Disorder Child Development Disorders, Pervasive Mental Disorders Diagnosed in Childhood Mental Disorders |
ClinicalTrials.gov processed this record on May 22, 2013