Study of the Molecular Genetics of Menstrual Migraine
The investigators hypothesize that genes that play a role in menstrual migraine can be identified using a well characterised migraine population and a comprehensive genome-wide association scan approach.
The aim of the study is to identify genes, genetic regions, and the effect of hormones on expression profiles in women with menstrual migraine compared to a control population with no personal or first-degree family history of migraine.
In this case control study, saliva samples will be taken from 300 cases and 300 controls for DNA analysis. Blood samples from 30 cases and 30 controls will be taken during the follicular phase as well as the luteal phase of the menstrual cycle for ribonucleic acid (RNA) analysis.
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||A Case-control Study of the Molecular Genetics of Menstrual Migraine (Pure Menstrual and Menstrually-related Migraine)|
- analyse DNA to determine if genes whose function already implicates them in migraine are more common in cases with menstrual migraine than in controls [ Time Frame: 6 years ] [ Designated as safety issue: No ]
- analyse RNA to examine if hormonal changes during menstruation affect the expression of the implicated genes [ Time Frame: 6 years ] [ Designated as safety issue: No ]
- analyse DNA to identify new genes that may be involved in menstrual migraine development [ Time Frame: 6 years ] [ Designated as safety issue: No ]
- analyse RNA to examine if hormonal changes during menstruation affect the expression of these genes [ Time Frame: 6 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Saliva Whole Blood
|Study Start Date:||November 2007|
|Estimated Study Completion Date:||November 2018|
|Estimated Primary Completion Date:||November 2013 (Final data collection date for primary outcome measure)|
1 Menstrual migraine
Caucasian women with a current or past history of menstrual migraine (MM = pure menstrual migraine or menstrually-related migraine) attending the City of London Migraine Clinic
2 No migraine
Caucasian women with no personal or first-degree family history of migraine
|The City of London Migraine Clinic|
|London, United Kingdom, EC1M 6DX|
|Principal Investigator:||E A MacGregor, MFSRH MD||The City of London Migraine Clinic|
|Principal Investigator:||Lyn Griffiths, BSc(Hons) PhD||Genomics Research Centre Griffith University|