Lebanese Interhospital Pneumococcal Surveillance Program (LIPSP)
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Purpose
Streptococcus pneumoniae (pneumococcus) is a bacterium that causes severe infections in children and adults such as meningitis, pneumonia, and blood stream infection. There are many types of these bacteria defined by the type of sugar coat that they have. These are classified as serotypes. There are common serotypes that cause severe disease and are preventable by vaccination of children. Other less common types are more difficult to prevent. The investigators aim to determine the serotypes that cause invasive pneumococcal disease in Lebanon and to study their sensitivity to different antibiotics. The investigators will collect bacterial isolates from different hospitals in Lebanon isolated from the blood or spinal fluid of patients with invasive pneumococcal disease. This information will help the investigators determine the usefulness of available pneumococcal vaccines in preventing these infections. The data will be distributed to all primary care physicians treating children in Lebanon and will be shared with the Ministry of Health.
| Condition |
|---|
|
Pneumonia Meningitis Sepsis Bacteremia |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Prospective |
| Official Title: | Lebanese Interhospital Pneumococcal Surveillance Program (LIPSP) |
- Serotype prevalence of S. pneumoniae in invasive pneumococcal disease [ Time Frame: yearly ] [ Designated as safety issue: No ]
- Determine the antibiotic sensitivity of S. pneumoniae and the association with specific serotypes [ Time Frame: yearly ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Bacterial isolates
| Estimated Enrollment: | 300 |
| Study Start Date: | October 2004 |
| Estimated Study Completion Date: | October 2014 |
| Estimated Primary Completion Date: | October 2013 (Final data collection date for primary outcome measure) |
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
patients with invasive pneumococcal disease with positive culture of S. pneumoniae from a normally sterile site (blood, CSF, etc.)
Inclusion Criteria:
Samples included in the study are those that are:
- culture proven
- invasive pneumococcal infections
- in patients of all ages admitted to different hospitals all over Lebanon
Acceptable samples include:
- positive isolates from blood
- cerebrospinal fluid
- other normally sterile body sites such as empyema fluid, abscesses, joint fluid, middle ear fluid obtained by tympanocentesis in the operating room, and lung needle aspiration
Exclusion Criteria:
- non S. pneumoniae isolates
Contacts and Locations| Contact: Ghassan S Dbaibo, M.D. | +961-1-749235 ext 5440 | gdbaibo@aub.edu.lb |
| Contact: Carelle Tabet, RN | +961-3-860129 | cnt@aub.edu.lb |
| Lebanon | |
| American University of Beirut | Recruiting |
| Beirut, Lebanon, 113-6044 | |
| Contact: Ghassan S Dbaibo, M.D. +961-1-749235 gdbaibo@aub.edu.lb | |
| Contact: Carelle Tabet, R.N. +961-3-860129 cnt03@aub.edu.lb | |
| Principal Investigator: Ghassan S Dbaibo, M.D. | |
| Principal Investigator: | Ghassan S Dbaibo, M.D. | American University of Beirut Medical Center |
More Information
No publications provided
| Responsible Party: | Dr. Ghassan Dbaibo, Professor, American University of Beirut Medical Center |
| ClinicalTrials.gov Identifier: | NCT00901602 History of Changes |
| Other Study ID Numbers: | PNEUMOSurv1LIPSP |
| Study First Received: | May 8, 2009 |
| Last Updated: | January 31, 2013 |
| Health Authority: | Lebanon: Institutional Review Board |
Keywords provided by American University of Beirut Medical Center:
|
streptococcus pneumoniae pneumococcus pneumonia meningitis |
serotypes bacteremia sepsis |
Additional relevant MeSH terms:
|
Bacteremia Meningitis Pneumonia Sepsis Bacterial Infections Infection Systemic Inflammatory Response Syndrome Inflammation |
Pathologic Processes Central Nervous System Infections Central Nervous System Diseases Nervous System Diseases Lung Diseases Respiratory Tract Diseases Respiratory Tract Infections |
ClinicalTrials.gov processed this record on May 23, 2013