Trial record 9 of 2386 for:    anemia

Tissue Sample Collection From Patients With Fanconi Anemia

This study is ongoing, but not recruiting participants.
Sponsor:
Collaborator:
Information provided by (Responsible Party):
OHSU Knight Cancer Institute
ClinicalTrials.gov Identifier:
NCT00899522
First received: May 9, 2009
Last updated: March 14, 2013
Last verified: March 2013
  Purpose

RATIONALE: Collecting and storing samples of tumor tissue from patients with Fanconi anemia to test in the laboratory may help the study of cancer in the future.

PURPOSE: This laboratory study is collecting and storing tumor tissue samples from patients with Fanconi anemia.


Condition Intervention
Fanconi Anemia
Unspecified Adult Solid Tumor, Protocol Specific
Unspecified Childhood Solid Tumor, Protocol Specific
Other: biologic sample preservation procedure
Procedure: biopsy

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Retrospective
Official Title: Fanconi Anemia Cancer Cell Repository

Resource links provided by NLM:


Further study details as provided by OHSU Knight Cancer Institute:

Primary Outcome Measures:
  • Creation of a Fanconi Anemia Cell Repository using rare solid tumor samples from patients with Fanconi anemia [ Time Frame: Duration of the study ] [ Designated as safety issue: No ]
  • Study tissue samples by molecular methods, including gene microarrays [ Time Frame: Duration of the study ] [ Designated as safety issue: No ]
  • Development of cancer cell lines from tissue archived from patients with Fanconi anemia [ Time Frame: Duration of the study ] [ Designated as safety issue: No ]

Estimated Enrollment: 120
Study Start Date: August 2005
Estimated Primary Completion Date: April 2013 (Final data collection date for primary outcome measure)
Intervention Details:
    Other: biologic sample preservation procedure
    Once the pathologist has taken the material needed to establish diagnosis of cancer, the anonymized snap-frozen and fresh samples will be either shipped to our laboratory for analysis or will be picked up by a member of the principal investigator's lab team. Samples will be stored indefinitely.
    Procedure: biopsy
    Once the pathologist has taken the material needed to establish diagnosis of cancer, 1-10 grams of the remaining tissue should be placed in phosphate buffered saline and shipped to the Bagby Lab.
Detailed Description:

OBJECTIVES:

  • Acquire rare solid tumor samples from patients with Fanconi anemia in order to create a Fanconi Anemia Cell Repository at the Oregon Health and Science University Cancer Institute.
  • Study repository tissue using a variety of molecular methods, including gene microarrays.
  • Develop cancer cell lines that are publicly available from tissue archived from patients with Fanconi anemia.

OUTLINE: Tumor biopsies are collected from patients with Fanconi anemia and archived for future molecular studies, cell line generation, and general usage by the research community at large. Medical information about the patient's cancer is also archived.

PROJECTED ACCRUAL: Not specified.

  Eligibility

Ages Eligible for Study:   1 Year to 55 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

To recruit participants into this project, an announcement will be posted on the Fanconi Anemia Research Fund website (http://www.fanconi.org/) after IRB approval is obtained.

Criteria

DISEASE CHARACTERISTICS:

  • Confirmed Fanconi anemia
  • Confirmed malignant solid tumor
  • Biopsy of tumor tissue available

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT00899522

Locations
United States, Oregon
Knight Cancer Institute at Oregon Health and Science University
Portland, Oregon, United States, 97239-3098
Sponsors and Collaborators
OHSU Knight Cancer Institute
Investigators
Principal Investigator: Grover C. Bagby, MD OHSU Knight Cancer Institute
  More Information

Additional Information:
No publications provided

Responsible Party: OHSU Knight Cancer Institute
ClinicalTrials.gov Identifier: NCT00899522     History of Changes
Other Study ID Numbers: CDR0000445453, P30CA069533, OHSU-HEM-03022-LX, OHSU-IRB00001100, OSHU-CR00003822
Study First Received: May 9, 2009
Last Updated: March 14, 2013
Health Authority: United States: Federal Government

Keywords provided by OHSU Knight Cancer Institute:
Fanconi anemia
unspecified adult solid tumor, protocol specific
unspecified childhood solid tumor, protocol specific

Additional relevant MeSH terms:
Anemia
Fanconi Anemia
Anemia, Hypoplastic, Congenital
Anemia, Aplastic
Fanconi Syndrome
Neoplasms
Hematologic Diseases
Bone Marrow Diseases
Genetic Diseases, Inborn
DNA Repair-Deficiency Disorders
Metabolic Diseases
Kidney Diseases
Urologic Diseases
Renal Tubular Transport, Inborn Errors
Metabolism, Inborn Errors

ClinicalTrials.gov processed this record on April 17, 2014