Tissue Sample Collection From Patients With Fanconi Anemia

• Creation of a Fanconi Anemia Cell Repository using rare solid tumor samples from patients with Fanconi anemia [ Time Frame: Duration of the study ] [ Designated as safety issue: No ]
  
• Study tissue samples by molecular methods, including gene microarrays [ Time Frame: Duration of the study ] [ Designated as safety issue: No ]
  
• Development of cancer cell lines from tissue archived from patients with Fanconi anemia [ Time Frame: Duration of the study ] [ Designated as safety issue: No ]
  

Other: biologic sample preservation procedure
Once the pathologist has taken the material needed to establish diagnosis of cancer, the anonymized snap-frozen and fresh samples will be either shipped to our laboratory for analysis or will be picked up by a member of the principal investigator's lab team. Samples will be stored indefinitely.
Procedure: biopsy
Once the pathologist has taken the material needed to establish diagnosis of cancer, 1-10 grams of the remaining tissue should be placed in phosphate buffered saline and shipped to the Bagby Lab.

OBJECTIVES:

• Acquire rare solid tumor samples from patients with Fanconi anemia in order to create a Fanconi Anemia Cell Repository at the Oregon Health and Science University Cancer Institute.
• Study repository tissue using a variety of molecular methods, including gene microarrays.
• Develop cancer cell lines that are publicly available from tissue archived from patients with Fanconi anemia.

OUTLINE: Tumor biopsies are collected from patients with Fanconi anemia and archived for future molecular studies, cell line generation, and general usage by the research community at large. Medical information about the patient's cancer is also archived.

PROJECTED ACCRUAL: Not specified.