Collecting and Storing Samples of Blood and Tumor Tissue From Patients With Osteosarcoma
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Purpose
RATIONALE: Collecting and storing samples of tumor tissue and blood from patients to test in the laboratory may help the study of cancer in the future.
PURPOSE: The purpose of this study is to collect and store samples of blood and tumor tissue from patients with osteosarcoma.
| Condition | Intervention |
|---|---|
|
Sarcoma |
Other: biologic sample preservation procedure |
| Study Type: | Observational |
| Official Title: | A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens |
- Collect biological specimens from patients with osteosarcoma [ Designated as safety issue: No ]
- Provide a repository for long-term storage of osteosarcoma-related biological materials [ Designated as safety issue: No ]
- Make these specimens available to qualified researchers to understand the biology of osteosarcoma [ Designated as safety issue: No ]
- Correlate these results with the patients' clinical data [ Designated as safety issue: No ]
| Study Start Date: | February 2008 |
OBJECTIVES:
- To collect biological specimens from patients with osteosarcoma at Children's Oncology Group (COG) institutions.
- To provide a repository for long-term storage of osteosarcoma-related biological materials.
- To make these specimens available to qualified researchers to understand the biology of osteosarcoma and correlate these results with the patients' clinical data.
OUTLINE: After the initial submission of blood samples, patients may undergo open or closed biopsy in order to obtain fresh and frozen tissue samples as well as paraffin embedded material. Patients who are enrolled at the time of initial diagnosis but then have a definitive surgery or develop recurrent disease may submit additional samples (paraffin block, frozen and fresh tumor tissue, or slides together with blood samples). Autopsy tumor samples may also be submitted.
Eligibility| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
All osteosarcoma patients seen at COG institutions are eligible, including the following:
- Newly diagnosed patients
- Patients with recurrent disease who were not enrolled at the time of diagnosis
The following specimens from the initial biopsy (and/or definitive surgery if an up-front resection is performed) are required:
- Paraffin embedded block OR 30 unstained slides
- Pretreatment blood consisting of 5 mL serum, 10 mL plasma, and 10 mL heparinized whole blood
- Fresh and frozen tumor specimens
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- Patients are not required to enter a therapeutic study to enroll on this study
Contacts and Locations
Show 155 Study Locations| Study Chair: | Richard Gorlick, MD | Children's Hospital at Montefiore |
More Information
Additional Information:
No publications provided
| ClinicalTrials.gov Identifier: | NCT00899275 History of Changes |
| Other Study ID Numbers: | CDR0000562538, COG-AOST06B1 |
| Study First Received: | May 9, 2009 |
| Last Updated: | November 22, 2012 |
| Health Authority: | Unspecified |
Keywords provided by National Cancer Institute (NCI):
|
osteosarcoma |
Additional relevant MeSH terms:
|
Osteosarcoma Sarcoma Neoplasms, Bone Tissue Neoplasms, Connective Tissue |
Neoplasms, Connective and Soft Tissue Neoplasms by Histologic Type Neoplasms |
ClinicalTrials.gov processed this record on May 23, 2013