Study of Kidney Tumors in Young Patients
RATIONALE: Collecting and storing samples of tumor tissue, blood, and urine from patients with cancer to study in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help the study of cancer in the future.
PURPOSE: This laboratory study is looking at kidney tumors in young patients.
Genetic: loss of heterozygosity analysis
Genetic: polymerase chain reaction
Genetic: polymorphism analysis
Other: immunohistochemistry staining method
Procedure: computed tomography
Procedure: magnetic resonance imaging
|Official Title:||Renal Tumors Classification, Biology, and Banking Study|
- 10-year disease-free survival [ Designated as safety issue: No ]
- 10-year overall survival [ Designated as safety issue: No ]
- Loss of heterozygosity [ Designated as safety issue: No ]
|Study Start Date:||February 2006|
- Classify patients with renal tumors by histological categorization, surgico-pathological stage, presence of metastases, age at diagnosis, tumor weight, and loss of heterozygosity for chromosomes 1p and 16q, to define eligibility for a series of therapeutic studies.
- Maintain a biological samples bank to make specimens available to scientists to evaluate additional potential biological prognostic variables and for the conduct of other research by scientists.
- Monitor outcome for those patients who are not eligible for a subsequent therapeutic study.
- Describe whether the pulmonary tumor burden correlates with outcome in patients with stage IV disease.
- Describe the sensitivity and specificity of abdominal CT scan by comparing it with surgical and pathologic findings for identification of local tumor spread beyond the renal capsule to adjacent muscle and organs, lymph node involvement at the renal hilum and in the retroperitoneum, preoperative tumor rupture, and metastases to the liver.
- Compare the sensitivity and specificity of pre-operative abdominal CT scan and MRI for the identification and differentiation of nephrogenic rests and Wilms' tumor in children with multiple renal lesions.
- Correlate the method of conception (natural vs assisted reproductive technology) with the development of Wilms' tumor.
OUTLINE: This is a multicenter study.
Tumor tissue, blood, and urine samples are collected for research studies, including immunohistochemistry. CT scans and MRIs are also performed. Loss of heterozygosity analyses (chromosome 1p and 16q) are performed by extraction of DNA. DNA polymorphisms are assayed by polymerase chain reaction using standard methodology. Leftover specimens are archived for future studies.
Patients are followed periodically for 5 years.
PROJECTED ACCRUAL: There are no sample size goals for this study.
Show 215 Study Locations
|Study Chair:||Paul E. Grundy, MD||Stollery Children's Hospital at University of Alberta Hospital|
|Investigator:||Jeffrey S. Dome, MD||St. Jude Children's Research Hospital|