Study of Stored Tumor Samples in Young Patients With Brain Tumors
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Purpose
This laboratory study is looking at stored tumor samples in young patients with brain tumors. Studying samples of tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
| Condition |
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Brain and Central Nervous System Tumors |
| Study Type: | Observational |
| Study Design: | Observational Model: Case-Only Time Perspective: Prospective |
| Official Title: | Molecular and Histopathologic Characterization of Atypical Teratoid Rhabdoid Tumors, Choroid Plexus Carcinomas, Ependymomas and Medulloblastoma/PNET of the Pediatric CNS |
- Relationship between molecular abnormalities and tumor histologic and clinical characteristics [ Time Frame: 10 Years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples With DNA
Fresh frozen, fixed and cultured tumor cells collected prospectively from a clinically well characterized patient cohort.
| Estimated Enrollment: | 200 |
| Study Start Date: | November 2004 |
| Estimated Study Completion Date: | November 2014 |
| Estimated Primary Completion Date: | November 2014 (Final data collection date for primary outcome measure) |
| Groups/Cohorts |
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Tumor/Tissue Sample
Tumor material collected prospectively from a clinically well characterized patient cohort
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Detailed Description:
The overall objective of this non-therapeutic protocol is to identify molecular abnormalities within prospectively treated pediatric CNS Atypical Teratoid Rhabdoid Tumors (ATRT), Choroid Plexus Carcinomas (CPC), and Ependymoma tumors and define the relationship between these abnormalities and tumor histologic and clinical characteristics. This objective will be achieved by applying state-of-the-art DNA, RNA and protein analysis tools to the study of fresh frozen, fixed and cultured tumor cells. The establishment of cell cultures from each tumor sample will also allow for in vitro analysis of tumor cell growth, signaling and therapeutic response.
Eligibility| Ages Eligible for Study: | up to 21 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Participants will have ATRT, CPC, medulloblastoma/PNET or ependymoma of the CNS as documented by the local neuropathologist. All studies will be conducted using tumor material collected prospectively from a clinically well characterized patient cohort.
Inclusion Criteria
- ATRT, CPC, medulloblastoma/PNET or ependymoma of the CNS as documented by the local neuropathologist. Tumor may be primary, progressive or relapsed disease.
- Age not more than 21 years at the time of initial diagnosis.
- Enrollment in the current version of the institution's banking protocol
Exclusion Criteria
- Diagnosis other than ATRT, CPC, medulloblastoma/PNET or ependymoma of the central nervous system.
- Age greater than 21 years at the time of diagnosis
Contacts and Locations| Contact: Amar Gajjar, MD | 1-866-278-5833 | info@stjude.org |
| United States, Tennessee | |
| St. Jude Children's Research Hospital | Recruiting |
| Memphis, Tennessee, United States, 38105 | |
| Contact: Amar Gajjar, MD 866-278-5833 info@stjude.org | |
| Principal Investigator: | Amar Gajjar, MD | St. Jude Children's Research Hospital |
| Principal Investigator: | Richard J. Gilbertson, MD, PhD | St. Jude Children's Research Hospital |
More Information
Additional Information:
No publications provided
| Responsible Party: | St. Jude Children's Research Hospital |
| ClinicalTrials.gov Identifier: | NCT00897286 History of Changes |
| Other Study ID Numbers: | NBTP01 |
| Study First Received: | May 9, 2009 |
| Last Updated: | January 24, 2013 |
| Health Authority: | United States: Institutional Review Board |
Keywords provided by St. Jude Children's Research Hospital:
|
childhood atypical teratoid/rhabdoid tumor childhood choroid plexus tumor childhood medulloblastoma recurrent childhood medulloblastoma childhood infratentorial ependymoma |
childhood supratentorial ependymoma recurrent childhood ependymoma recurrent childhood supratentorial primitive neuroectodermal tumor untreated childhood supratentorial primitive neuroectodermal tumor |
Additional relevant MeSH terms:
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Ependymoma Medulloblastoma Nervous System Neoplasms Central Nervous System Neoplasms Rhabdoid Tumor Glioma Neoplasms, Neuroepithelial Neuroectodermal Tumors Neoplasms, Germ Cell and Embryonal |
Neoplasms by Histologic Type Neoplasms Neoplasms, Glandular and Epithelial Neoplasms, Nerve Tissue Neuroectodermal Tumors, Primitive Neoplasms by Site Nervous System Diseases Neoplasms, Complex and Mixed |
ClinicalTrials.gov processed this record on May 19, 2013